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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
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Regional and neuraxial anaesthesia

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Neurological or cardiorespiratory deterioration after a block

Rapidly rising sensory or motor block, dyspnoea, arm weakness, bradycardia, hypotension, altered consciousness, severe back pain or a new progressive neurological deficit can indicate high neuraxial block, compressive haematoma, local-anaesthetic toxicity or another time-critical complication.

Action: Stop further local anaesthetic, call senior anaesthetic help, give oxygen, support airway, ventilation and circulation, identify the likely complication, and obtain urgent specialist assessment and imaging when neuraxial compression is possible.

Synopsis

Select, perform and follow adult peripheral or central neuraxial anaesthesia safely by matching technique, consent, coagulation status, monitoring and rescue planning to the procedure.

  • Distinguish peripheral nerve block, fascial-plane block, spinal anaesthesia and epidural anaesthesia: each has different onset, spread, duration, failure pattern and bleeding consequence.
  • Before needling, confirm indication, alternatives, consent, side and site, infection, neurological baseline, drug allergies, total local-anaesthetic plan and an agent-specific anticoagulant interval.
  • Treat a high neuraxial block as an evolving airway and circulation emergency: call for help, give 100% oxygen, support ventilation, treat hypotension and bradycardia, and reassure an aware patient.

Key red flags

Difficulty breathing, inability to speak normally, arm weakness, bradycardia or hypotension after spinal or epidural dosing suggests a high or total neuraxial block and requires immediate airway and circulatory support.

New severe spinal pain, motor weakness, sensory loss or bladder and bowel dysfunction after neuraxial intervention may represent an epidural haematoma or abscess; urgent neurological assessment and MRI must not wait for routine ward review.

Tinnitus, metallic taste, circumoral paraesthesia, agitation, seizure, conduction disturbance or cardiovascular collapse during or after injection may be local-anaesthetic systemic toxicity.

Never apply one anticoagulant interval to every block: neuraxial and deep non-compressible blocks carry greater bleeding consequence than superficial compressible techniques, and timing changes with agent, dose, renal function and traumatic puncture.

Pain out of proportion, increasing analgesic requirement or pain on passive stretch despite a functioning lower-limb block can indicate compartment syndrome and needs urgent surgical assessment.

A block on the wrong side, wrong site or wrong patient is prevented by an active stop-before-you-block check immediately before needle insertion.

High neuraxial block

Ascending numbness, hypotension, bradycardia, dyspnoea, arm weakness and impaired consciousness may progress rapidly to apnoea.

Neuraxial compression

New back pain with progressive motor, sensory or sphincter dysfunction is a neurological emergency requiring urgent imaging and surgical discussion.

Compartment syndrome

Disproportionate escalating pain, pain on passive stretch, tense swelling or neurological change requires immediate surgical assessment even when regional analgesia is present.

Reasoning priorities

01
Medication and last-dose record

Determine whether antithrombotic timing is compatible with the exact planned technique.

Check agent, dose, indication, renal function, last administration and catheter plan against current drug-specific guidance; do not infer safety from the medicine class alone.

Worked reasoning

Worked case: anticoagulationEpidural requested in an anticoagulated adult

An adult scheduled for major abdominal surgery takes an antithrombotic and requests epidural analgesia.

  1. Identify the exact drug, dose, indication, renal function, last dose, other haemostatic abnormalities and both the procedural bleeding risk and consequence of neuraxial bleeding.
  2. Use the current agent-specific neuraxial table for insertion and catheter removal; if the interval is unmet, choose an alternative analgesic technique rather than improvising a shortened gap.
  3. Record postoperative thromboprophylaxis timing, catheter observations and who authorises removal and restart so that prescriptions cannot inadvertently overlap an unsafe catheter window.
  4. If traumatic puncture occurs or neurological symptoms develop, stop routine progression, seek senior advice and arrange urgent assessment under the applicable escalation pathway.

Key medicines

Local anaesthetic for regional blockSelect agent, concentration and volume for the target and keep the cumulative dose within the product-specific limit.Reduce exposure in frailty or organ dysfunction, account for all infiltration and infusion sources, aspirate and inject incrementally where appropriate, and keep lipid rescue immediately available.
Vasopressor for neuraxial hypotensionUse small titrated intravenous boluses or an infusion selected for heart rate and haemodynamic context.Avoid a fixed universal dose; severe bradycardia, haemorrhage, anaphylaxis and high block require cause-specific resuscitation and senior anaesthetic support.
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Sources and review status3 sources · checked 13 Sept 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 13 Sept 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom