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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
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Axillary lump differential diagnosis

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Synopsis

Develop the ability to localise an axillary lump to lymph node, skin, accessory breast or soft tissue and use breast, systemic and infective features to direct urgent investigation, while explaining uncertainty and arranging reliable review.

  • Decide first whether the axillary lump is a lymph node, skin lesion, abscess, lipoma, vascular structure or hormonally responsive accessory breast tissue.
  • Ask about breast symptoms, melanoma or other cancers, fever and weight loss, recent vaccination, upper-limb wounds, shaving, hidradenitis and pregnancy or lactation.
  • Examine the lump’s depth, tenderness, mobility and skin relation, then assess both breasts, upper limbs, supraclavicular fossae and other nodal stations.

Investigation priorities

01
Axillary ultrasoundFirst step

Distinguish a lymph node from a superficial or soft-tissue mass and evaluate cortical and hilar morphology.

Management branches

Worked case: integrated breast assessmentApply axillary lump differential diagnosis to a defined presentation

A 62-year-old has a hard 2 cm left axillary lump, no breast symptoms and no recent vaccination or infection; breast palpation is normal.

  1. Map the axillary lesion and examine breasts, supraclavicular areas, skin and upper limb, while asking about systemic symptoms, prior cancers, infection and immunisation.
  2. Arrange urgent breast-service assessment because an unexplained axillary lump in an adult can represent occult breast cancer or another malignancy despite normal breast palpation.
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Sources and review status3 sources · checked 7 Sept 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Apply principles in context and verify current guidance when a decision affects care. Source check completed 7 Sept 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom