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Rapidsynchronised cardioversiondefibrillationadenosineprocainamideamiodaroneanticoagulation

Electrical cardioversion and antiarrhythmic drugs

Essential points for quick revision.

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Escalate

For tachyarrhythmia with shock, severe hypotensive syncope, myocardial ischaemia, severe pulmonary oedema or immediately after ROSC, perform synchronised cardioversion. If the patient becomes pulseless, disable synchronisation and use the cardiac-arrest defibrillation pathway.

Synopsis

Deliver synchronised cardioversion safely, choose rhythm-specific energy and use emergency antiarrhythmics in their correct licensed or resuscitation context.

  • Synchronised cardioversion times the shock to the R wave to avoid energy delivery during ventricular repolarisation.
  • A conscious patient needs carefully titrated sedation or anaesthesia, but instability must not be allowed to worsen while waiting.
  • RCUK 2025 energies: AF at maximum defibrillator output; flutter/regular narrow tachycardia 70-120 J; VT with a pulse 120-150 J.

Key red flags

Unstable tachyarrhythmia

Shock, syncope with severe or ongoing hypotension, myocardial ischaemia, severe pulmonary oedema or immediately post-ROSC favours immediate electricity.

Investigation priorities

01
12-lead ECGFirst step

Define rhythm, regularity, QRS width, QT, pre-excitation and ischaemia.

Management branches

unstableImmediate synchronised cardioversion

A perfusing tachyarrhythmia causes a life-threatening adverse feature.

  1. Call expert and anaesthetic help, perform ABCDE assessment, attach pads, monitor continuously and obtain IV access.
  2. Sedate or anaesthetise a conscious patient with careful haemodynamic planning when feasible without dangerous delay.
narrowStable regular narrow tachycardia

QRS is under 120 ms, rhythm regular and no adverse feature is present.

Key medicines

AdenosineRCUK March 2026: 6 mg, then 12 mg, then 18 mg by very rapid IV bolus, each followed by a rapid flush. This algorithm-specific sequence differs from the cited product SmPC's licensed 3 mg, 6 mg, then 12 mg sequence.
Procainamide10-15 mg/kg IV over 20 minutes, maximum 1 g.
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Sources and review status7 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom