DPDoctor's PassportEducation
Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
RapidMLAMSRAGP

Phototherapy and systemic treatment principles

Essential points for quick revision.

!
Escalate

Generalised pustular psoriasis, erythroderma or systemic deterioration needs immediate same-day specialist treatment; routine outpatient phototherapy or slow systemic escalation is not an emergency substitute.

Synopsis

Select and sequence specialist psoriasis treatment beyond topicals, obtain informed consent, prevent phototherapy and medicine harm, and monitor response using skin, joint and life-impact outcomes.

  • NICE offers narrowband UVB to plaque or guttate psoriasis not controlled with topical treatment alone; two or three sessions weekly are options, with faster response commonly achieved at three.
  • Phototherapy is prescribed treatment, not advice to sunbathe: consent covers burns, photosensitivity, photoageing, cumulative skin-cancer risk, attendance and eye or genital protection where required.
  • Do not use phototherapy routinely as maintenance; change strategy after poor tolerance, inadequate response, rapid relapse beyond half of baseline within three months, impractical access or especially high skin-cancer risk.

Key red flags

Fever, diffuse pustules, extensive tender inflammation, haemodynamic change or reduced urine output requires acute specialist assessment before routine treatment selection.

Unstable disease

Generalised pustulation, erythroderma, fever, malaise, fluid loss or physiological deterioration bypasses routine outpatient sequencing and needs same-day specialist treatment.

Investigation priorities

01
First-line baseline severity and impactFirst stepFirst line

Confirm treatment eligibility and provide a comparator for response across skin, high-impact sites and quality of life.

Management branches

First-line phototherapyNarrowband UVB course

Plaque or guttate psoriasis not controlled by topical treatment alone and no urgent instability.

  1. Confirm diagnosis, extent, skin cancer and photosensitivity history, medicines, previous ultraviolet exposure, ability to attend and informed consent.
  2. Offer supervised narrowband UVB two or three times weekly; explain that three sessions weekly may achieve response faster while total course and doses remain unit-prescribed.

Key medicines

MethotrexateStart incrementally, for example 5 to 10 mg orally once weekly, and increase to the effective dose up to 25 mg once weekly; assess after 3 months at target dose.
CiclosporinGive 2.5 to 3 mg/kg/day orally in 2 divided doses; increase towards 5 mg/kg/day after 4 weeks for non-response, or sooner only when rapid control is necessary.
Open full textbook Answer 2 questions
Sources and review status8 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom