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Acute and chronic rhinosinusitis

Essential points for quick revision.

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Sinus symptoms with eye or neurological changes

Periorbital swelling, displaced globe, diplopia, painful or restricted eye movements, reduced vision, frontal swelling, severe frontal headache or focal neurology can indicate complicated sinusitis.

Action: Refer immediately to hospital for ENT and ophthalmic or neurological assessment; do not manage these findings with a routine outpatient antibiotic prescription.

Synopsis

Separate self-limiting acute infection from persistent sinonasal inflammation, prescribe antibiotics selectively, and escalate orbital or intracranial complications without delay.

  • An uncomplicated acute episode usually lasts two to three weeks, and most patients do not need antibiotics.
  • Symptoms for around ten days or less generally warrant supportive care with explicit deterioration advice.
  • After at least ten days without improvement, consider a fourteen-day high-dose intranasal corticosteroid course in adults and children aged twelve or over.

Key red flags

New eye swelling with diplopia, restricted movement or visual change requires immediate hospital assessment for orbital spread.

Investigation priorities

01
Clinical assessment without routine imagingFirst step

Identify uncomplicated acute disease and exclude immediate complications.

Management branches

Early uncomplicated illnessSupport recovery without antibiotics

Symptoms have lasted around ten days or less without significant systemic illness.

  1. Explain the expected course and offer suitable analgesia with attention to individual contraindications.
  2. Saline may be tried for comfort, while explaining that evidence for symptom relief in acute sinusitis is limited.

Key medicines

Phenoxymethylpenicillin for uncomplicated acute sinusitis when antibiotics are indicatedFor adults aged eighteen or over, give 500 mg orally four times daily for five days, following NICE NG79 when an antibiotic is appropriate.
Co-amoxiclav for higher-risk or second-choice treatmentFor adults, give 500/125 mg orally three times daily for five days. NICE selects it initially for systemic illness or high complication risk, or after deterioration on a first-choice antibiotic for at least two to three days.
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Sources and review status4 sources · checked 7 Sept 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 7 Sept 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom