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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Diabetic foot assessment, infection and ulceration

Endocrinology and metabolism · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Escalate

A diabetic foot ulcer with sepsis, spreading soft-tissue infection, deep abscess, gangrene, critical limb ischaemia, rapidly progressive tissue loss or suspected compartment involvement needs immediate acute admission and surgical, vascular and multidisciplinary diabetic-foot input. A red, hot, swollen foot with neuropathy can be acute Charcot arthropathy even when pain is modest and radiographs are normal; make the patient non-weight-bearing and obtain urgent specialist assessment. Do not wait for a routine clinic or start antibiotics as a substitute for drainage, perfusion assessment and offloading.

Synopsis

Stratify diabetic foot risk, recognise limb- and life-threatening disease, coordinate multidisciplinary ulcer care, and avoid diagnostic or antibiotic shortcuts that delay healing.

  • Every diabetes foot review should inspect skin, nails, callus, deformity and footwear, test protective sensation and assess arterial supply in both feet.
  • Risk rises with neuropathy, PAD, deformity, callus, previous ulcer or amputation and renal replacement therapy; follow-up intensity follows the highest feature.
  • Active problems include ulceration, infection, ischaemia, gangrene and suspected acute Charcot arthropathy and require rapid foot-service referral rather than annual review.
  • Refer limb- or life-threatening problems immediately; refer other active diabetic foot problems to the multidisciplinary foot care service within one working day.
  • Clinical infection is diagnosed from local or systemic inflammatory features, not from a positive swab or the mere presence of an open ulcer.
  • Clean and debride before obtaining a deep tissue or bone sample when feasible; superficial swabs often describe colonisers and can misdirect antibiotics.
  • For mild diabetic foot infection in adults, NICE first-choice oral flucloxacillin is 500 mg to 1 g four times daily for 7 days; use the severity table, allergies, renal function and microbiology, and review intravenous therapy by 48 hours.
  • Ulcer treatment requires pressure offloading, perfusion review, debridement, appropriate dressing, infection control and glucose or nutrition optimisation as one coordinated plan.
  • A normal or raised ankle pressure can mislead in calcified diabetic arteries; combine Doppler waveforms, toe measures and vascular judgement when PAD is suspected.

Key red flags

Ischaemic tissue loss

Rest pain, pallor, coolness, absent pulses, delayed capillary refill, toe necrosis or a punched-out margin suggests PAD and requires urgent vascular assessment.

Spreading infection

Expanding erythema, warmth, swelling, tenderness, purulent discharge, systemic illness, crepitus or disproportionate pain raises deep infection and surgical urgency.

Acute Charcot foot

Unilateral warmth, oedema, erythema and shape change in a neuropathic foot can mimic cellulitis or gout. Normal early radiographs do not make weight-bearing safe.

Investigation priorities

01
Full bilateral foot examinationFirst step

Define wound severity, neuropathy, deformity, skin threat and arterial supply at the bedside.

Management branches

PreventStratify and protect

A person with diabetes attends routine review without a current active foot problem.

  1. Inspect both feet and footwear, test protective sensation, assess pulses and identify deformity, callus, previous ulcer or amputation and renal replacement therapy.
  2. Assign the NICE risk category, explain it in practical language and refer to foot-protection services at the required interval rather than recording risk without action.
  3. Teach daily inspection, safe nail and skin care, correctly fitting footwear and avoidance of barefoot walking or direct heat, with an immediate contact route for new change.

Key medicines

Flucloxacillin for mild diabetic foot infectionGive immediate-release flucloxacillin 500 mg to 1 g orally four times daily for 7 days; clinical assessment may justify up to a further 7 days, with microbiology-guided narrowing when available.Check immediate penicillin hypersensitivity, hepatic history, renal function, interactions and ability to absorb oral treatment. The 1 g four-times-daily dose is off label; reassess promptly if worsening or no improvement within 1–2 days.
Clarithromycin when flucloxacillin is unsuitableGive clarithromycin 500 mg orally twice daily for 7 days for mild infection; clinical assessment may justify up to a further 7 days, guided by microbiology when available.Check QT risk, macrolide interactions, hepatic and renal function and pregnancy. Verify the allergy phenotype and local resistance, and use microbiology to narrow or change treatment.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE NG19 diabetic foot recommendationsRecommendations 1.6.6–1.6.15 and antibiotic tables support prompt treatment, adult doses, oral-first choice where appropriate, 48-hour IV review and reassessment.
  • NICE NG19 antimicrobial visual summaryCurrent severity-based diabetic foot infection prescribing and review pathway.
  • NICE NG28 type 2 diabetes complicationsCurrent annual foot review and neuropathy context within long-term diabetes care.
  • NICE CG147 peripheral arterial disease recommendationsNational vascular assessment, imaging and revascularisation principles relevant to ischaemic diabetic wounds.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom