Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
Diabetic foot assessment, infection and ulceration
Essential points for quick revision.
2 min synopsisUK scopeSources checked 27 Aug 2026Clinical review pending
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Escalate
A diabetic foot ulcer with sepsis, spreading soft-tissue infection, deep abscess, gangrene, critical limb ischaemia, rapidly progressive tissue loss or suspected compartment involvement needs immediate acute admission and surgical, vascular and multidisciplinary diabetic-foot input. A red, hot, swollen foot with neuropathy can be acute Charcot arthropathy even when pain is modest and radiographs are normal; make the patient non-weight-bearing and obtain urgent specialist assessment. Do not wait for a routine clinic or start antibiotics as a substitute for drainage, perfusion assessment and offloading.
Synopsis
Stratify diabetic foot risk, recognise limb- and life-threatening disease, coordinate multidisciplinary ulcer care, and avoid diagnostic or antibiotic shortcuts that delay healing.
Every diabetes foot review should inspect skin, nails, callus, deformity and footwear, test protective sensation and assess arterial supply in both feet.
Risk rises with neuropathy, PAD, deformity, callus, previous ulcer or amputation and renal replacement therapy; follow-up intensity follows the highest feature.
Active problems include ulceration, infection, ischaemia, gangrene and suspected acute Charcot arthropathy and require rapid foot-service referral rather than annual review.
Key red flags
Ischaemic tissue loss
Rest pain, pallor, coolness, absent pulses, delayed capillary refill, toe necrosis or a punched-out margin suggests PAD and requires urgent vascular assessment.
Investigation priorities
01
Full bilateral foot examinationFirst step
Define wound severity, neuropathy, deformity, skin threat and arterial supply at the bedside.
Management branches
PreventStratify and protect
A person with diabetes attends routine review without a current active foot problem.
Inspect both feet and footwear, test protective sensation, assess pulses and identify deformity, callus, previous ulcer or amputation and renal replacement therapy.
Assign the NICE risk category, explain it in practical language and refer to foot-protection services at the required interval rather than recording risk without action.
Key medicines
Flucloxacillin for mild diabetic foot infectionGive immediate-release flucloxacillin 500 mg to 1 g orally four times daily for 7 days; clinical assessment may justify up to a further 7 days, with microbiology-guided narrowing when available.
Clarithromycin when flucloxacillin is unsuitableGive clarithromycin 500 mg orally twice daily for 7 days for mild infection; clinical assessment may justify up to a further 7 days, guided by microbiology when available.
National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.
NICE NG19 diabetic foot recommendationsRecommendations 1.6.6–1.6.15 and antibiotic tables support prompt treatment, adult doses, oral-first choice where appropriate, 48-hour IV review and reassessment.