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Anal fissure

Essential points for quick revision.

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Escalate

A fissure itself rarely causes physiological instability. Fever, spreading erythema, fluctuance, immunocompromise with severe pain, necrosis, inability to examine because pain is disproportionate, or a suspicious indurated ulcer requires urgent assessment for abscess, Fournier gangrene or malignancy.

Synopsis

Recognise a typical anal fissure, identify atypical secondary causes, and sequence bowel regulation, topical sphincter relaxation and continence-preserving specialist intervention.

  • The classic symptom is sharp tearing pain during defaecation followed by burning or spasm lasting minutes to hours, often with a small amount of bright blood.
  • Most primary fissures are posterior midline; an anterior fissure can occur, particularly after childbirth, but lateral or multiple fissures require investigation for secondary disease.
  • Chronic fissures show exposed sphincter fibres, a sentinel skin tag or hypertrophied anal papilla and persist despite basic bowel measures.

Key red flags

Atypical location or number

Lateral, multiple, painless, irregular or broad ulcers raise Crohn disease, HIV-related or sexually transmitted infection, tuberculosis, haematological disease, trauma or anal cancer and warrant specialist assessment.

Investigation priorities

01
Gentle perianal inspectionFirst step

Confirm site, chronic features and competing visible pathology.

Management branches

InitialTypical acute fissure care

A concordant painful midline tear without secondary-disease features.

  1. Explain the pain–spasm–constipation cycle, provide gentle hygiene advice and offer warm shallow bathing and non-constipating analgesia for symptom relief.
  2. Make stool consistently soft using gradual dietary fibre, adequate fluids and a formulary laxative; address diarrhoea as actively as constipation when it is the trigger.

Key medicines

Macrogol or another suitable laxativeTitrate the locally preferred product until stool is soft and easily passed.
Glyceryl trinitrate rectal ointmentApply the licensed preparation according to current BNF instructions for the full course.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom