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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
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GI endoscopy, biopsy and capsule studies

Essential points for quick revision.

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Escalate

Severe or increasing chest or abdominal pain, tachycardia, fever, subcutaneous emphysema, dyspnoea or peritonism after endoscopy may indicate perforation. Keep the patient nil by mouth, resuscitate, obtain urgent cross-sectional imaging and involve senior endoscopy and surgical teams. Significant bleeding, hypoxia, reduced consciousness or aspiration requires parallel emergency stabilisation.

Synopsis

Select upper endoscopy, colonoscopy, targeted biopsy or capsule examination for the clinical question; prepare and consent the patient safely; and recognise bleeding, perforation, sedation injury and capsule retention promptly.

  • Choose the test by the suspected anatomical site and whether tissue or therapy is needed: capsule endoscopy visualises but cannot biopsy, insufflate, wash or treat.
  • Urgent endoscopy follows stabilisation in major gastrointestinal bleeding, obstruction or foreign-body emergencies; airway, circulation and senior support come first.
  • Consent must be procedure- and patient-specific, including alternatives, sedation choices, likely biopsy or therapy and material risks such as bleeding, perforation, aspiration and missed lesions.

Key red flags

Need for emergency therapeutic endoscopy

Ongoing haematemesis, melaena with shock, variceal bleeding, obstructing food bolus with inability to handle secretions or a dangerous foreign body needs urgent specialist endoscopy after immediate stabilisation.

Investigation priorities

01
Upper GI endoscopyFirst step

Inspect and treat oesophageal, gastric and duodenal disease in dysphagia, upper bleeding, mucosal disease, selected anaemia and surveillance indications.

Management branches

ChooseMatch procedure to question

A gastrointestinal symptom or abnormal test warrants luminal investigation.

  1. Define the anatomical hypothesis, urgency and need for tissue or therapy, and review prior endoscopy and imaging quality.
  2. Select OGD, colonoscopy, flexible sigmoidoscopy, enteroscopy, capsule or a non-endoscopic alternative with the gastroenterology pathway.

Key medicines

MidazolamTitrate small intravenous increments to the minimum effective conscious-sedation level under the BSG and local endoscopy protocol; use substantially less in frail, older or comorbid adults.
FentanylUse small titrated intravenous doses only within the local endoscopy-sedation protocol, accounting for age, frailty, opioid exposure and concurrent benzodiazepine.
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Sources and review status6 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom