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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Large-bowel obstruction and pseudo-obstruction

Gastroenterology and hepatology · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Peritonism, continuous severe pain, fever with toxicity, shock, metabolic acidosis, free air, pneumatosis, portal venous gas, a closed-loop obstruction or poor bowel-wall enhancement suggests ischaemia or perforation. Keep the patient fasting, resuscitate, give locally indicated antimicrobials and obtain immediate senior colorectal and anaesthetic review. Do not give neostigmine or attempt routine endoscopic decompression before mechanical obstruction and doubtful bowel viability are excluded.

Synopsis

Differentiate mechanical large-bowel obstruction from acute colonic pseudo-obstruction, detect threatened caecum or bowel early, and sequence resuscitation, decompression, stenting or surgery safely.

  • Mechanical large-bowel obstruction has a physical transition point, most often colorectal cancer, diverticular stricture or volvulus; pseudo-obstruction has diffuse functional dilatation without that lesion.
  • Progressive distension, colicky pain, obstipation and later faeculent vomiting are typical, but partial obstruction may still pass liquid stool or flatus.
  • A competent ileocaecal valve can create a closed loop between an obstructing distal lesion and the valve, rapidly increasing caecal tension and perforation risk.
  • Contrast CT defines the transition, cause, proximal diameter, metastatic disease and signs of ischaemia or perforation; a plain radiograph alone rarely completes planning.
  • Initial care is fasting, venous access, fluid and electrolyte correction, analgesia, antiemetic treatment, nasogastric decompression when vomiting and urgent colorectal review.
  • Malignant left-sided obstruction may be managed with emergency surgery or expert endoscopic stenting as palliation or selected bridge to surgery after multidisciplinary assessment.
  • Acute colonic pseudo-obstruction often follows surgery, severe illness, trauma, metabolic disturbance or motility-suppressing medicines and commonly dilates caecum and right colon.
  • Pseudo-obstruction starts with treating the precipitant, stopping anticholinergic and opioid burdens, correcting potassium and magnesium, mobilisation and serial diameter assessment.

Key red flags

Distal mechanical obstruction

Progressive abdominal distension, colicky pain and obstipation with a CT transition at an annular mass or benign stricture supports mechanical large-bowel obstruction and needs urgent colorectal planning.

Closed-loop danger

A distal block with a competent ileocaecal valve produces marked caecal dilatation without small-bowel decompression. Increasing pain, tenderness or reduced enhancement threatens caecal perforation.

Volvulus

Abrupt distension and obstruction with a twist, whirl or beak on CT indicates sigmoid or caecal volvulus. Viability and anatomical type determine endoscopic versus operative treatment.

Toxic megacolon

Systemic toxicity with colonic dilatation during severe ulcerative, Crohn's or infectious colitis is not simple pseudo-obstruction and requires urgent medical-colorectal management with anti-inflammatory or infection-directed care.

Investigation priorities

01
Contrast CT abdomen and pelvisFirst step

Locate a transition point, identify tumour, stricture or twist, distinguish pseudo-obstruction and assess bowel viability and perforation.

Management branches

Mechanical obstructionResuscitate and define a transition

Distension, colic and obstipation suggest an occluding colonic lesion.

  1. Keep fasting, obtain venous access, correct fluid and electrolyte deficits, provide analgesia and antiemetic treatment, and insert a nasogastric tube when vomiting or proximal dilatation warrants it.
  2. Perform rectal and hernia examination, send urgent bloods and obtain contrast CT with direct radiology discussion about transition, caecal risk, metastases and viability.
  3. Call senior colorectal surgery early and involve anaesthesia or critical care for physiological compromise; give local antibiotics when perforation, ischaemia or sepsis is suspected.
  4. Choose resection, diversion or expert stenting according to cause, site, viability, curative intent, comorbidity and available service, documenting stoma and perforation trade-offs.

Key medicines

Intravenous crystalloid and electrolytesGive reassessed isotonic fluid and replace potassium or magnesium through the current hospital protocol, accounting for kidney function, cardiac reserve and measured deficits.Avoid blind large-volume administration in heart or renal failure and monitored potassium over-replacement. Biochemical correction does not resolve a mechanical transition or threatened bowel.
NeostigmineUse only the specialist-approved intravenous regimen in a monitored area after CT excludes mechanical obstruction and the team confirms viable bowel and appropriate resuscitation support.Mechanical obstruction, peritonitis and doubtful viability are contraindications. Bradycardia, asystole and bronchospasm can occur; continuous monitoring, immediate resuscitation capability and atropine availability are required.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • ACPGBI emergency colorectal surgery consensusEmergency obstruction assessment, bowel viability and operative principles.
  • NICE NG151 colorectal cancerStenting and surgery choices for acute malignant left-sided large-bowel obstruction.
  • RCSEng acute colonic pseudo-obstruction reviewRoyal College review of conservative, pharmacological and endoscopic decompression.
  • Neostigmine injection SmPCContraindications, bradycardia and bronchospasm warnings, administration and atropine requirement.
  • ACPGBI malignant obstruction position statementsSpecialist position on malignant large-bowel obstruction and stenting pathways.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Rapid draft
Authoring state
Clinical stateAwaiting review
JurisdictionUnited Kingdom