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Large-bowel obstruction and pseudo-obstruction

Essential points for quick revision.

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Escalate

Peritonism, continuous severe pain, fever with toxicity, shock, metabolic acidosis, free air, pneumatosis, portal venous gas, a closed-loop obstruction or poor bowel-wall enhancement suggests ischaemia or perforation. Keep the patient fasting, resuscitate, give locally indicated antimicrobials and obtain immediate senior colorectal and anaesthetic review. Do not give neostigmine or attempt routine endoscopic decompression before mechanical obstruction and doubtful bowel viability are excluded.

Synopsis

Differentiate mechanical large-bowel obstruction from acute colonic pseudo-obstruction, detect threatened caecum or bowel early, and sequence resuscitation, decompression, stenting or surgery safely.

  • Mechanical large-bowel obstruction has a physical transition point, most often colorectal cancer, diverticular stricture or volvulus; pseudo-obstruction has diffuse functional dilatation without that lesion.
  • Progressive distension, colicky pain, obstipation and later faeculent vomiting are typical, but partial obstruction may still pass liquid stool or flatus.
  • A competent ileocaecal valve can create a closed loop between an obstructing distal lesion and the valve, rapidly increasing caecal tension and perforation risk.

Key red flags

Distal mechanical obstruction

Progressive abdominal distension, colicky pain and obstipation with a CT transition at an annular mass or benign stricture supports mechanical large-bowel obstruction and needs urgent colorectal planning.

Investigation priorities

01
Contrast CT abdomen and pelvisFirst step

Locate a transition point, identify tumour, stricture or twist, distinguish pseudo-obstruction and assess bowel viability and perforation.

Management branches

Mechanical obstructionResuscitate and define a transition

Distension, colic and obstipation suggest an occluding colonic lesion.

  1. Keep fasting, obtain venous access, correct fluid and electrolyte deficits, provide analgesia and antiemetic treatment, and insert a nasogastric tube when vomiting or proximal dilatation warrants it.
  2. Perform rectal and hernia examination, send urgent bloods and obtain contrast CT with direct radiology discussion about transition, caecal risk, metastases and viability.

Key medicines

Intravenous crystalloid and electrolytesGive reassessed isotonic fluid and replace potassium or magnesium through the current hospital protocol, accounting for kidney function, cardiac reserve and measured deficits.
NeostigmineUse only the specialist-approved intravenous regimen in a monitored area after CT excludes mechanical obstruction and the team confirms viable bowel and appropriate resuscitation support.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom