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Perianal Crohn disease

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Synopsis

Recognise perianal sepsis promptly, map fistula anatomy and rectal inflammation, and combine drainage, continence-preserving surgery and effective Crohn therapy through a specialist multidisciplinary service.

  • Perianal Crohn disease includes abscess, fistula, ulceration, fissure, skin tags, stenosis and rectovaginal or anovaginal disease; it may precede recognised luminal inflammation.
  • Pain, fever or swelling is an abscess until assessed; urgent examination and drainage take priority over escalating biologic treatment or waiting for elective MRI.
  • Pelvic MRI and examination under anaesthesia are complementary: MRI maps tracts and occult collections, while EUA confirms openings and permits drainage or seton placement.

Key red flags

Perianal pain with fever, spreading cellulitis, urinary retention, immunosuppression or sepsis requires urgent colorectal assessment and drainage; antibiotics alone are insufficient source control.

Investigation priorities

01
Pelvic MRIFirst step

Map primary tract, sphincter relation, secondary branches, horseshoe extension and abscess.

Management branches

SEPSISDrain before immunosuppression

Pain, swelling, fever, systemic upset or imaging suggests a perianal abscess.

  1. Assess ABCDE, analgesia, antibiotics for systemic infection and urgent colorectal review, recognising that deep sepsis can lack a visible fluctuant lump.
  2. Proceed to timely examination under anaesthesia and incision or internal drainage; obtain MRI first only when stable and it will not postpone source control.

Key medicines

InfliximabWeight-based induction and maintenance through a specialist fistulising Crohn protocol.
Antibiotic adjunctShort culture- and local-protocol-guided course for cellulitis, sepsis or postoperative drainage.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom