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Epiglottitis and deep-neck-space infection

Essential points for quick revision.

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Threatened upper airway

Drooling, stridor, tripod posture, muffled voice, severe odynophagia, rapidly progressive neck swelling or toxic appearance can precede complete obstruction.

Action: Keep the patient upright and calm, give high-flow oxygen if tolerated, summon senior anaesthesia and ENT immediately and prepare a controlled difficult-airway plan. Do not force throat examination, lie the patient flat or send an unstable patient unescorted to imaging.

Synopsis

Recognise impending upper-airway obstruction, avoid destabilising examination, secure the airway with senior anaesthetic and ENT expertise, and combine intravenous antimicrobials with drainage of deep collections.

  • Airway safety comes before diagnostic certainty; keep a distressed patient upright and avoid procedures that may precipitate obstruction.
  • Adult epiglottitis often presents with severe throat pain, dysphagia, muffled voice and minimal oropharyngeal findings; stridor is a late warning.
  • Deep-neck infection follows tonsillar, dental, salivary, traumatic or instrument-related infection and may spread between fascial planes into the mediastinum.

Key red flags

Stridor, drooling, inability to swallow secretions or exhaustion indicates critical airway narrowing requiring immediate expert control.

Epiglottic phenotype

Severe odynophagia, drooling, quiet muffled speech and preference to sit forward with little visible pharyngeal inflammation is a high-risk pattern.

Investigation priorities

01
Continuous airway and physiological assessmentFirst step

Detect deterioration before complete obstruction.

Management branches

ASSESSProtect the airway

Upper-airway infection is suspected from pain, voice, swallowing or neck findings.

  1. Keep the patient upright, calm and nil by mouth while experienced anaesthesia and ENT attend with difficult-airway equipment.
  2. Avoid tongue depression, unnecessary cannulation attempts and unmonitored transfer when obstruction is plausible.

Key medicines

Ceftriaxone for severe epiglottic infectionGive ceftriaxone 2 g intravenously once daily in adults, using meningitis dosing if central nervous system infection is suspected.
Co-amoxiclav for polymicrobial deep-neck infectionGive co-amoxiclav 1.2 g intravenously every 8 hours for severe odontogenic or polymicrobial deep-neck infection when local guidance supports it.
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Sources and review status3 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom