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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Epiglottitis and deep-neck-space infection

Infectious diseases, microbiology and sexual health · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Threatened upper airway

Drooling, stridor, tripod posture, muffled voice, severe odynophagia, rapidly progressive neck swelling or toxic appearance can precede complete obstruction.

Action: Keep the patient upright and calm, give high-flow oxygen if tolerated, summon senior anaesthesia and ENT immediately and prepare a controlled difficult-airway plan. Do not force throat examination, lie the patient flat or send an unstable patient unescorted to imaging.

Synopsis

Recognise impending upper-airway obstruction, avoid destabilising examination, secure the airway with senior anaesthetic and ENT expertise, and combine intravenous antimicrobials with drainage of deep collections.

  • Airway safety comes before diagnostic certainty; keep a distressed patient upright and avoid procedures that may precipitate obstruction.
  • Adult epiglottitis often presents with severe throat pain, dysphagia, muffled voice and minimal oropharyngeal findings; stridor is a late warning.
  • Deep-neck infection follows tonsillar, dental, salivary, traumatic or instrument-related infection and may spread between fascial planes into the mediastinum.
  • Flexible nasendoscopy is performed only by an experienced team where immediate airway rescue is available; unstable patients proceed to controlled airway management.
  • Contrast CT neck and chest maps deep collections after the airway is secure; imaging must not delay intervention in a deteriorating patient.
  • Start intravenous ceftriaxone-based or local broad oral-flora treatment after blood cultures when safe, adding anaerobic and resistant-organism cover by source and exposure.
  • A mature parapharyngeal, retropharyngeal or odontogenic abscess usually requires drainage and removal of the dental or other source.
  • Review frequently for increasing oxygen need, secretion intolerance, swelling, cranial neuropathy, jugular thrombosis and mediastinal extension.

Key red flags

Stridor, drooling, inability to swallow secretions or exhaustion indicates critical airway narrowing requiring immediate expert control.

Trismus, floor-of-mouth elevation, tongue displacement or rapidly spreading submandibular swelling suggests Ludwig angina and difficult intubation.

Neck swelling with chest pain, crepitus or sepsis can indicate descending mediastinitis and needs urgent cross-sectional imaging after airway safety.

Severe pain with little visible tonsillar change can reflect epiglottitis or a deep parapharyngeal process rather than uncomplicated pharyngitis.

Epiglottic phenotype

Severe odynophagia, drooling, quiet muffled speech and preference to sit forward with little visible pharyngeal inflammation is a high-risk pattern.

Peritonsillar spread

Unilateral throat pain, hot-potato voice, uvular deviation and trismus suggests a peritonsillar collection requiring ENT drainage assessment.

Ludwig angina

Bilateral woody submandibular swelling, raised tongue and dental infection creates rapidly worsening airway difficulty.

Deep-space complication

Neck stiffness, torticollis, cranial neuropathy, septic emboli or chest symptoms indicates extension beyond superficial pharyngitis.

Investigation priorities

01
Continuous airway and physiological assessmentFirst step

Detect deterioration before complete obstruction.

Management branches

ASSESSProtect the airway

Upper-airway infection is suspected from pain, voice, swallowing or neck findings.

  1. Keep the patient upright, calm and nil by mouth while experienced anaesthesia and ENT attend with difficult-airway equipment.
  2. Avoid tongue depression, unnecessary cannulation attempts and unmonitored transfer when obstruction is plausible.
  3. Obtain rapid observations, glucose and cultures without postponing airway control; use controlled theatre intubation or surgical airway according to anatomy.
  4. After stabilisation, examine dental, tonsillar, salivary and traumatic sources and choose contrast imaging with the operating team.

Key medicines

Ceftriaxone for severe epiglottic infectionGive ceftriaxone 2 g intravenously once daily in adults, using meningitis dosing if central nervous system infection is suspected.Check immediate beta-lactam allergy, biliary disease, renal and liver context and local resistance; airway control must never wait for antibiotic effect.
Co-amoxiclav for polymicrobial deep-neck infectionGive co-amoxiclav 1.2 g intravenously every 8 hours for severe odontogenic or polymicrobial deep-neck infection when local guidance supports it.Avoid in immediate penicillin allergy or previous co-amoxiclav liver injury, adjust for renal function and do not let treatment postpone drainage.
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Sources and review status3 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE NG240 meningitis recommendationsEmergency assessment and ceftriaxone dosing when meningitis remains possible.
  • UKHSA Haemophilus influenzae type b Hib Green Book chapter 16National Hib epidemiology, vaccination and public-health context relevant to epiglottitis.
  • British Association of Otorhinolaryngology clinical resourcesUK ENT airway and deep-neck professional resources.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom