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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Human and animal bites

Infectious diseases, microbiology and sexual health · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Deep hand, vascular or systemic emergency

Sepsis, rapidly spreading infection, neurovascular compromise, open fracture, joint penetration, tendon injury or a clenched-fist wound threatens life or long-term function.

Action: Use ABCDE when unwell, irrigate and dress the wound, give indicated intravenous antimicrobials and obtain immediate hand, orthopaedic, plastics or surgical review for exploration, repair and deep cultures.

Synopsis

Assess bite depth and anatomical injury, irrigate and debride early, select proportionate antimicrobial prophylaxis or treatment and complete tetanus, rabies and blood-borne-virus prevention.

  • Document species, ownership and health, location and country, provocation, time, wound mechanism and the patient's immune and vaccination status.
  • Immediate high-volume irrigation, removal of foreign material and appropriate debridement reduces inoculum and allows true depth assessment.
  • Examine distal perfusion, sensation, tendon function and joint movement before local anaesthetic or repair whenever possible.
  • Human bites contain oral streptococci, staphylococci, anaerobes and Eikenella; cat punctures commonly inoculate Pasteurella deep into tissue.
  • NICE first-choice oral prophylaxis and treatment is co-amoxiclav 625 mg three times daily: three days for prophylaxis and five days for treatment.
  • In penicillin allergy when pregnancy is excluded, NICE uses doxycycline 200 mg on day one then 100 to 200 mg daily plus metronidazole 400 mg three times daily.
  • Do not close infected, heavily contaminated or high-risk puncture wounds routinely; facial wounds and selected clean wounds need specialist closure judgment.
  • Assess tetanus for every wound, rabies for relevant mammalian or bat exposure and hepatitis B, hepatitis C and HIV risk after human bites involving blood.

Key red flags

A clenched-fist wound over a metacarpophalangeal joint can penetrate tendon and joint despite a tiny opening.

Reduced movement, severe pain on passive motion or tendon dysfunction suggests sheath, joint or structural injury.

Absent pulse, delayed capillary return, sensory loss or uncontrolled bleeding requires emergency surgical assessment.

Fever, lymphangitis, rapidly spreading erythema or hypotension indicates invasive infection and possible sepsis.

Deep puncture to hand, face, genitals, foot or near a prosthetic joint has high functional or infection consequence.

An overseas mammalian exposure or bat contact requires urgent rabies-risk assessment without waiting for symptoms.

Clenched-fist injury

A small dorsal wound over a metacarpophalangeal joint after punching teeth may track through extensor tendon into the joint.

Cat puncture pattern

Narrow deep punctures, particularly to hand or near a joint, can seal over and develop rapid Pasteurella cellulitis, tenosynovitis or abscess.

Dog crush and tear

Dog bites may cause irregular laceration, tissue devitalisation, fracture and nerve or vascular injury in addition to bacterial inoculation.

Flexor sheath involvement

Fusiform swelling, flexed posture, tenderness along the sheath and pain on passive extension requires emergency hand-surgical evaluation.

Exposure prevention risk

Investigation priorities

01
Wound exploration and functional examinationFirst step

Define depth, devitalised tissue, retained tooth, tendon, joint, nerve and vascular injury.

Management branches

CLEANIrrigate and define anatomy

Any human or animal bite has broken the skin or caused crush injury.

  1. Control bleeding, remove jewellery, provide analgesia and irrigate copiously with potable water or saline while removing visible contamination and foreign material.
  2. Record species, location, timing, provocation, country, animal availability, host immune status, allergies and vaccination history.
  3. Assess depth, tissue viability, perfusion, sensation, tendon function and joint penetration and obtain radiography when tooth, fracture or joint injury is possible.
  4. Refer hand, face, genital, neurovascular, tendon, joint, fracture or extensive-crush injuries for specialist exploration and closure decisions.

Key medicines

Co-amoxiclavGive 625 mg orally three times daily for three days as prophylaxis or five days as treatment for an adult bite wound.Check immediate penicillin allergy, renal function and previous co-amoxiclav liver injury; review at 24 to 48 hours and extend only for a supported deep or slow response.
Doxycycline plus metronidazoleGive doxycycline 200 mg orally on day one then 100 to 200 mg daily, plus metronidazole 400 mg orally three times daily, for three prophylaxis days or five treatment days.Avoid doxycycline in pregnancy, separate it from iron and antacids, counsel about photosensitivity and oesophagitis, and review metronidazole alcohol and warfarin interactions.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE NG184 Human and animal bites antimicrobial prescribing
  • Rabies post-exposure treatment: management guidelines
  • Tetanus: the green book, chapter 30
  • NICE BNF Bites human and animal treatment summary

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom

Bat exposure, overseas mammalian bite, uncertain tetanus vaccination or human blood contamination triggers separate urgent prevention assessment.