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Post-exposure prophylaxis for meningococcal disease

Essential points for quick revision.

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Symptoms override prophylaxis

Fever, severe headache, neck stiffness, photophobia, confusion, severe limb pain, mottling or a non-blanching rash in a contact may be invasive meningococcal disease rather than asymptomatic carriage.

Action: Use ABCDE, call emergency services, obtain cultures when this causes no delay and give immediate meningitis or sepsis treatment. Do not send a symptomatic contact home with a prophylaxis dose or wait for the index case typing.

Synopsis

Identify genuine close contacts of meningococcal disease, distinguish prophylaxis from treatment, deliver rapid single-dose or alternative carriage eradication safely, and coordinate notification, vaccination and symptom action with health protection.

  • Notify suspected meningococcal disease immediately; the health-protection team, not an informal contact list, defines who receives prophylaxis.
  • Close contacts usually include household-like exposure, intimate kissing and direct unprotected contact with respiratory secretions around the infectious period.
  • Healthcare staff need prophylaxis only after direct exposure to large-droplet secretions without appropriate protection, such as airway resuscitation.

Key red flags

Any invasive symptom in a contact triggers emergency treatment, not a chemoprophylaxis appointment.

Direct secretion exposure

Unprotected mouth-to-mouth resuscitation, intubation splash or intimate kissing creates a carriage exposure that health protection evaluates promptly.

Investigation priorities

01
Clinical symptom screenFirst step

Separate asymptomatic contacts from people who may already have invasive disease.

Management branches

ASSESSDefine the exposed contact

A probable or confirmed meningococcal case creates concern among contacts.

  1. Notify health protection and provide secure index-case, onset, setting and exposure information for a formal contact assessment.
  2. Ask every potential contact about symptoms first and divert symptomatic people to emergency care without clinic delay.

Key medicines

Ciprofloxacin meningococcal prophylaxisGive ciprofloxacin 500 mg orally once to an eligible adult contact when susceptibility and safety permit.
Ceftriaxone prophylaxisGive ceftriaxone 250 mg intramuscularly once to an eligible adult when selected, including pregnancy-compatible use.
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Sources and review status3 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom