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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Ankle sprain and syndesmotic injury

Musculoskeletal medicine and orthopaedics · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Deformity, ischaemia and unstable syndesmosis need urgent orthopaedics

Gross deformity, threatened skin, absent pulse, progressive neurological loss, compartment features, open injury or suspected fracture-dislocation requires immediate reduction and trauma care; high ankle pain with proximal fibular tenderness may represent an unstable Maisonneuve-pattern injury.

Action: Use trauma ABCDE, document skin and complete neurovascular findings, urgently reduce a threatened dislocation with adequate analgesia, obtain orthogonal ankle and full-length tibia-fibula imaging as indicated, immobilise, keep weight-bearing restricted and involve orthopaedics immediately for instability or limb threat.

Synopsis

Assess ankle trauma without missing fracture, syndesmotic instability or proximal fibular injury, use Ottawa criteria and weight-bearing imaging appropriately, and deliver early functional rehabilitation with timely escalation of unstable patterns.

  • Do not begin with the label sprain: inspect deformity and skin, document pulses and nerves, palpate the entire fibula, malleoli, navicular, fifth-metatarsal base and Achilles, then test function.
  • Use the Ottawa ankle and foot rules to decide first-line radiography in alert adults: posterior malleolar, navicular or fifth-base tenderness or inability to take four steps warrants films.
  • Lateral sprain produces tenderness over the anterior talofibular and sometimes calcaneofibular ligaments; delayed anterior drawer or talar tilt may be more informative after acute guarding settles.
  • Syndesmotic injury causes pain above the mortise with external rotation, dorsiflexion or calf squeeze and often a slower recovery than an ordinary lateral sprain.
  • First-line management of an uncomplicated lateral sprain is short protection, compression and elevation followed promptly by weight-bearing as tolerated, range, strength and balance rehabilitation.
  • First-line imaging for suspected unstable syndesmosis is weight-bearing ankle radiography when safe, with full-length tibia-fibula views for proximal tenderness; MRI is the reference soft-tissue test when instability remains uncertain.
  • Restrict weight-bearing and arrange urgent orthopaedic review when syndesmotic diastasis, associated fracture, deltoid disruption or marked clinical instability is suspected; fixation may be required.
  • Prevent recurrence with progressive peroneal and calf strength, dorsiflexion, balance, hopping and sport-specific change-of-direction work, adding taping or a brace for higher-risk return.

Key red flags

A deformed ankle, tented skin, open wound, cool foot, delayed refill or new sensory and motor loss requires immediate reduction and orthopaedic care.

Pain above the ankle joint, positive external-rotation or squeeze provocation and inability to bear weight out of proportion to swelling raises syndesmotic injury.

Tenderness along the proximal fibula or medial ankle after rotational trauma suggests a Maisonneuve pattern and requires full-leg imaging.

Bony tenderness at the posterior malleolar edges, navicular or base of fifth metatarsal, or inability to take four steps activates Ottawa radiography criteria.

Persistent severe pain, tense swelling, passive-stretch pain or worsening neurology requires compartment and occult fracture assessment.

A hot swollen ankle with fever, skin breach or bacteraemic risk needs septic-joint evaluation, not a routine sprain pathway.

Investigation priorities

01
First-line Ottawa-rule assessmentFirst stepFirst line

Select patients who need ankle or foot radiographs after acute injury while screening for rule exclusions.

02
First-line ankle and foot radiographs when indicatedFirst line

Detect malleolar, talar, fifth-metatarsal, navicular and alignment injury.

Management branches

First-lineExclude fracture and limb threat

An acute ankle injury presents without immediate need for trauma resuscitation.

  1. Inspect skin and alignment and document pulses, refill, sensation and motor function before stress testing.
  2. Apply Ottawa criteria, palpate the entire fibula and assess Achilles, midfoot and fifth-metatarsal base.
  3. Obtain ankle, foot or full-leg radiographs according to the anatomical findings and restrict loading until important injury is excluded.
  4. Reduce and escalate immediately for deformity, threatened skin or neurovascular compromise rather than waiting for routine imaging.
Lateral sprainMove early after brief protection

Fracture and unstable syndesmotic injury are unlikely and the pattern is an isolated stable lateral sprain.

  1. Use a supportive brace, compression, elevation and compatible analgesia, allowing weight-bearing as pain permits.
  2. Begin ankle range promptly, then progress calf and peroneal strength and single-leg balance.
  3. Advance to hopping, landing and change-of-direction tasks before full sport or hazardous work.
  4. Reassess in one to two weeks if weight-bearing and function are not improving or if locking and deep pain emerge.

Key medicines

Paracetamol for acute ankle painUse 500–1000 mg orally as required, leaving 4 hours or longer between doses and limiting the 24-hour total to 4 g; lower that ceiling for low body weight, frailty, malnutrition or liver risk.Check all combination products and alcohol or hepatic risk; analgesia does not make an unstable mortise safe to load.
Topical diclofenac gelSpread 2–4 g of diclofenac 1.16% gel over intact painful ankle skin per application, up to three or four times daily for a brief course within the licensed maximum.Avoid wounds, significant skin abrasion and NSAID hypersensitivity, account for other NSAIDs and pregnancy, and do not conceal worsening compartment or infection pain.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • BOFAS Hyperbook Ankle SprainsLateral and syndesmotic assessment, imaging and management.
  • NICE NG38 Fractures Non-complex RecommendationsOttawa ankle and foot rule use and fracture pathways.
  • NHS Sprains and StrainsEarly self-care, movement and escalation advice.
  • BOAST Management of Ankle FracturesNeurovascular documentation, urgent reduction and syndesmotic stability in fracture patterns.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom