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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Humeral-shaft fracture and radial-nerve injury

Musculoskeletal medicine and orthopaedics · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Open, vascular or progressive nerve injury

Most closed primary radial palsies recover, but open wounds, arterial compromise, penetrating trauma or a new deficit after manipulation can indicate laceration or entrapment needing urgent action.

Action: Perform ABCDE after high energy, cover open wounds and give intravenous prophylaxis within one hour, document pulses and named radial, median and ulnar functions, align and splint, and seek immediate orthopaedic, vascular or nerve input for tissue threat.

Synopsis

Stabilise humeral-shaft fracture, document radial and wider neurovascular function accurately, distinguish primary from new iatrogenic palsy, and select functional bracing, fixation or nerve exploration safely.

  • Inspect the whole arm for wounds, deformity and skin pressure and examine shoulder and elbow because associated joint injury changes care.
  • Before and after splintage, test wrist extension, finger MCP extension, thumb extension, dorsal first-web sensation, median and ulnar functions, pulses and refill.
  • Obtain AP and lateral radiographs of the full humerus including shoulder and elbow; pathological features may require staging before definitive fixation.
  • A closed primary radial palsy is commonly observed with fracture treatment and serial recovery assessment rather than explored automatically.
  • Open fracture, vascular injury, penetrating laceration, irreducible entrapment or a new post-manipulation palsy lowers the threshold for urgent exploration.
  • Many closed suitable fractures use initial splintage followed by a functional brace, with early shoulder and elbow movement and alignment review.
  • Operative fixation is considered for open, vascular, pathological, polytrauma, segmental, failed closed or functionally unacceptable patterns.
  • Provide a wrist-extension splint and hand therapy for radial palsy to preserve grasp, joint position and passive range during nerve recovery.

Key red flags

A cool hand, absent pulse, expanding arm haematoma or recurrent bleeding requires immediate realignment and combined vascular and orthopaedic assessment.

A wound near the shaft, penetrating mechanism or exposed bone triggers the open long-bone pathway and early antibiotic prophylaxis.

A radial deficit first appearing after reduction, splintage or fixation requires urgent reassessment for entrapment, compression or iatrogenic injury.

Shaft fracture

Arm pain, swelling, shortening, angulation and crepitus follow direct or torsional trauma.

Radial palsy

Wrist, finger and thumb extension weakness with dorsal first-web sensory change produces wrist drop.

Secondary palsy

A new deficit after manipulation, brace fitting or fixation raises concern for compression, entrapment or iatrogenic injury.

Arterial injury

Pulse loss, coolness, delayed refill or expanding swelling requires immediate limb-saving coordination.

Investigation priorities

01
Full-length AP and lateral humeral radiographsFirst step

Define fracture and include both shoulder and elbow joints.

Management branches

First assessmentAlign and map nerve function

A humeral-shaft fracture is suspected after trauma.

  1. Use ABCDE for high energy, expose wounds and inspect shoulder, arm and elbow.
  2. Give analgesia and document pulses and radial, median and ulnar motor and sensory findings.
  3. Obtain full-length films, align and splint and repeat the identical examination.

Key medicines

Paracetamol for adult arm-fracture painFor an adult, prescribe 500 mg to 1 g orally as required, with a minimum 4-hour interval and a maximum of four administrations in one day.Reduce the limit in low body weight or hepatic risk and count all combination products.
Intravenous prophylaxis for an open humerusGive the locally approved intravenous open-fracture agent and dose as soon as possible and within 1 hour, adjusted for allergy, renal function and contamination.Do not delay for imaging or cultures, and do not use continued antibiotics to compensate for inadequate excision.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • AO Surgery Reference humeral-shaft fractures
  • BOAST peripheral nerve injury
  • BOAST open fractures
  • NICE NG38 fractures non-complex assessment and management

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom