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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Trauma in pregnancy, older people and anticoagulated patients

Musculoskeletal medicine and orthopaedics · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Atypical physiology does not reduce urgency

Pregnancy can conceal loss, frailty can turn low-energy injury into major trauma, and anticoagulation can produce delayed or disproportionate bleeding despite initially reassuring observations.

Action: Treat maternal and general CABCDE threats immediately, use manual uterine displacement in later pregnancy, activate senior obstetric, geriatric, trauma and haematology support as relevant, obtain indicated imaging without harmful delay, and reverse life-threatening anticoagulant-associated bleeding through the current agent-specific protocol.

Synopsis

Adapt trauma assessment to altered physiology, frailty and antithrombotic exposure while preserving standard life-saving priorities, timely imaging, haemorrhage control and medication reversal.

  • Use the standard trauma sequence for all three groups; differences modify thresholds, positioning, doses and follow-up rather than replacing CABCDE priorities.
  • Resuscitate the pregnant patient first and avoid supine aortocaval compression in later pregnancy with manual uterine displacement or left tilt that does not compromise spinal care.
  • Do not withhold necessary CT or contrast because of pregnancy; discuss optimisation promptly, but maternal diagnosis and survival take priority over theoretical radiation risk.
  • Involve obstetrics early, determine gestation and rhesus status, and arrange fetal assessment appropriate to viability after maternal stabilisation; give anti-D according to the maternity protocol when indicated.
  • Treat low-energy falls in frail older people as potentially major: fully expose, examine spine, chest, pelvis and head, reconcile baseline cognition and mobility and use a lower imaging threshold.
  • Identify anticoagulant name, indication, last dose, adherence, renal function and interacting drugs immediately; send coagulation tests but recognise routine PT or APTT may not exclude direct-oral-anticoagulant effect.
  • For warfarin-associated traumatic intracranial haemorrhage, NICE supports immediate prothrombin-complex concentrate with intravenous vitamin K through the emergency reversal protocol.
  • After haemostasis, reassess reversal, thromboprophylaxis and anticoagulant restart daily with the relevant specialist because both recurrent bleeding and thrombosis are time-dependent.

Key red flags

Pregnancy with shock, abdominal pain, vaginal bleeding, uterine tenderness, contractions or reduced fetal movement requires maternal resuscitation plus immediate obstetric assessment for abruption, uterine injury and fetal compromise.

An older person with new confusion, inability to mobilise, focal spine or groin pain, chest-wall tenderness or anticoagulant exposure may have major occult injury after a seemingly minor fall.

Head impact, neurological change, persistent vomiting, unexplained haemoglobin fall, expanding bruising or hypotension in an anticoagulated patient requires urgent imaging, drug identification and reversal planning.

Investigation priorities

01
First-line maternal trauma assessmentFirst stepFirst line

Identify life threats and pregnancy modifiers without delaying resuscitation.

02
Preferred CT when serious injury is suspectedPreferred

Diagnose maternal head, spine, thoracic, abdominal or pelvic injury accurately.

Management branches

PregnancyResuscitate mother and assess fetus

A pregnant patient has sustained potentially significant trauma.

  1. Run CABCDE, provide spinal protection as indicated and use manual uterine displacement or compatible left tilt in later pregnancy while treating maternal threats.
  2. Activate trauma, anaesthetic and obstetric teams, establish gestation and rhesus status and control haemorrhage with standard maternal priorities.
  3. Proceed with the best indicated maternal imaging after rapid radiology optimisation; do not substitute limited ultrasound for necessary CT.
  4. After stabilisation, monitor fetus and uterine activity according to gestation and symptoms and follow the maternity anti-D and fetomaternal-haemorrhage pathway.

Key medicines

Four-factor prothrombin-complex concentrate for warfarin reversalFor emergency warfarin reversal, use the selected four-factor PCC product's INR- and weight-based intravenous regimen; for Beriplex, factor IX doses are 25, 35 or 50 IU/kg at INR 2–3.9, 4–6 or above 6, capped at 2,500, 3,500 or 5,000 IU respectively.Give with intravenous vitamin K under the emergency protocol, recheck INR and watch for thrombosis; confirm product-specific dosing because units and maximums must not be transferred between PCC brands.
Phytomenadione for emergency warfarin reversalGive vitamin K1 5–10 mg by slow intravenous injection with PCC for severe bleeding, following the current local reversal protocol and selected product instructions.Intravenous administration can rarely cause serious hypersensitivity, so give slowly with monitoring; vitamin K alone acts too slowly for life-threatening haemorrhage and can complicate later anticoagulation restart.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE NG39 Major trauma: assessment and initial management
  • NICE NG232 Head injury: assessment and early management
  • Resuscitation Council UK 2025 special circumstances guidelines
  • Beriplex P/N 500 IU Summary of Product Characteristics

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom