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Cranial nerve examination

Essential points for quick revision.

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Escalate

Sudden visual loss, a painful pupil-involving third-nerve palsy, acute multiple cranial neuropathies, papilloedema with deteriorating neurology, new dysphagia or secretion failure, acute ophthalmoplegia with limb signs, or facial weakness within a possible stroke syndrome requires immediate senior neuro-ophthalmic, stroke, neurological, airway or imaging assessment.

Synopsis

Examine the afferent, efferent and brainstem functions of the cranial nerves systematically, then localise single and multiple deficits while recognising neuro-ophthalmic and bulbar emergencies.

  • Start with observation of eyelid position, pupil size, eye alignment, facial symmetry, voice, articulation, secretion handling and spontaneous eye movements before following a numbered sequence.
  • Test visual acuity in each eye with habitual correction before interpreting colour, fields, pupils or fundi; a binocular result can hide severe unilateral impairment.
  • Confrontation fields localise pre-chiasmal, chiasmal and retrochiasmal dysfunction only as a screen. Repeat carefully and arrange formal perimetry or urgent imaging when the history and field defect require it.

Key red flags

Optic-nerve dysfunction

Monocular acuity or colour loss, a central field defect, relative afferent pupillary defect and disc swelling or later pallor suggests optic neuropathy. Pain on eye movement favours optic neuritis but is neither required nor specific.

Investigation priorities

01
Monocular acuity, colour and visual-field assessmentFirst step

Quantify afferent visual dysfunction and determine whether the pattern is pre-chiasmal, chiasmal or retrochiasmal.

Management branches

Painful ophthalmoplegiaExclude aneurysm and compression

Sudden diplopia or ptosis with ocular-motor deficit, pupillary abnormality, severe headache, orbital signs or additional neurology.

  1. Perform ABCDE, glucose, acuity, pupils, fields, eye position and movements, face and limb examination; document onset, pain, trauma, anticoagulation, diabetes and vascular history.
  2. Discuss immediately with stroke, neurology, ophthalmology and neuroradiology according to local arrangements and obtain urgent vascular and structural imaging suited to aneurysm, stroke, cavernous sinus or orbital disease.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom