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Progestogen-only pill, implant and injection

Essential points for quick revision.

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Assess failure before routine replacement

A missed pill outside its product window, injection beyond the accepted interval, expired implant, interacting enzyme inducer or pregnancy symptoms after recent intercourse may represent contraceptive failure.

Action: Establish exact product and dates, offer emergency contraception when indicated, restart or bridge according to method-specific rules and arrange pregnancy testing 21 days after the latest risk.

Synopsis

Select and use progestogen-only pills, the etonogestrel implant and injectable contraception safely, with exact timing, bleeding, interaction, bone-health and fertility-return counselling.

  • Progestogen-only methods avoid oestrogen and are suitable for many people who cannot use CHC, but current breast cancer and some serious liver or vascular conditions still alter eligibility.
  • Know the pill formulation: traditional norethisterone or levonorgestrel POP has a three-hour late window, desogestrel a 12-hour window and drospirenone a 24-hour window with different missed-pill rules.
  • The etonogestrel implant is over 99% effective and, following the 2026 UK licence extension, provides contraception for five years; check the actual insertion and replacement date.

Key red flags

Severe abdominal pain, collapse or bleeding with a positive pregnancy test needs urgent ectopic-pregnancy assessment even though absolute pregnancy risk on these methods is low.

Investigation priorities

01
Pregnancy-risk assessmentFirst step

Identify emergency contraception, safe initiation and repeat-testing needs after missed or late use.

Management branches

Method selectionMatch duration and reversibility

A patient wants an oestrogen-free hormonal method.

  1. Compare daily pill timing, a five-year removable implant and a 13-week injection that cannot be withdrawn, including typical effectiveness and privacy.
  2. Apply UKMEC and assess enzyme inducers, bleeding priorities, future pregnancy timing, weight and bone-health factors relevant to DMPA.

Key medicines

Desogestrel 75 microgram progestogen-only pillTake one tablet orally at the same time every day without a pill-free interval; a dose more than 12 hours late is missed and requires the product-specific missed-pill pathway.
Drospirenone 4 mg progestogen-only pillTake one active tablet orally daily for 24 days followed by four inactive tablets in each 28-day pack; use its 24-hour missed-pill window and formulation-specific instructions.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom