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Fragility fracture and secondary prevention

Essential points for quick revision.

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Acute fracture and dangerous secondary causes

Suspected hip fracture, unstable vertebral fracture with neurological deficit, compartment or neurovascular compromise, multiple fractures, hypercalcaemia, unexplained destructive lesion or fracture with constitutional symptoms requires urgent treatment before routine osteoporosis work-up.

Action: Immobilise and handle safely, provide prompt analgesia, assess neurovascular and neurological status, obtain appropriate imaging and urgent orthopaedic or spinal review; investigate malignancy, myeloma, infection or severe metabolic disturbance when the mechanism or imaging is atypical.

Synopsis

Recognise low-trauma fracture as a sentinel event, investigate skeletal and fall contributors without delaying treatment in high-risk people, and deliver coordinated fracture-liaison, osteoporosis, exercise and safety care that prevents the next fracture.

  • A fragility fracture usually follows force equivalent to a fall from standing height or less and is a clinical signal for prompt secondary prevention.
  • First-line after acute care is fracture-liaison or equivalent coordinated assessment of fracture site, prior fractures, falls, medicines, nutrition, secondary causes and future risk.
  • Do not delay treatment simply to obtain DXA when an older person with a recent fragility fracture is already at high or very high risk and treatment is indicated.

Key red flags

Inability to weight bear or pain on hip rotation after a standing-height fall requires hip-fracture assessment even if the initial radiograph is normal.

Hip fragility fracture

Groin pain, shortened externally rotated leg or inability to weight bear after low trauma requires urgent hip imaging.

Investigation priorities

01
Fracture confirmation and site imagingFirst step

Define the acute injury and stability.

Management branches

First-line post-fracture sequenceTreat promptly during the imminent-risk period

A low-trauma fracture is confirmed or strongly suspected.

  1. Complete acute fracture care and identify previous and occult vertebral fractures, falls and secondary-cause clues.
  2. Estimate risk and obtain DXA only when it will refine management without delaying indicated therapy.

Key medicines

Alendronic acid70 mg orally once weekly; take on rising after an overnight fast with plain water, remain upright and avoid food, drink and other medicines for at least 30 minutes.
Zoledronic acid5 mg by intravenous infusion once yearly, with infusion duration and renal checks according to the product information.
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Sources and review status7 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom