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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Vaccination and infection prevention in later life

Medicine of older adults · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Severe vaccine reaction or outbreak illness

Anaphylaxis after vaccination, severe respiratory or sepsis physiology, meningococcal features, rapidly spreading shingles in immunosuppression or a care-home outbreak with vulnerable residents requires immediate clinical and public-health action.

Action: Use ABCDE and intramuscular adrenaline for anaphylaxis under the emergency protocol, treat acute infection, isolate proportionately, notify the relevant health-protection service and begin source-specific outbreak control without waiting for every test result.

Synopsis

Use the current UK immunisation programme and layered infection-prevention measures to reduce serious respiratory, shingles, pneumococcal and care-associated disease while adapting consent, timing, contraindications and delivery for frailty and care settings.

  • Check the live UK routine schedule and Green Book at every review because age cohorts, products and seasonal eligibility can change.
  • Offer annual influenza vaccination to current eligible older adults and risk groups before the main season, without missing later opportunities.
  • COVID-19 vaccination follows the current seasonal JCVI and national campaign; do not assume last year's age threshold or product.
  • The adult RSV programme offers a single dose at the routine age and current catch-up cohort, with eligibility confirmed from the live schedule.
  • Shingrix is a non-live two-dose shingles vaccine used in the current age and immunosuppressed cohorts, with interval determined by immune status.
  • Offer the current national pneumococcal vaccine to eligible age and clinical-risk groups and verify prior doses, as programme product can change.
  • First-line vaccine assessment checks records, age and risk eligibility, immune suppression, pregnancy where relevant, allergy phenotype, acute illness and consent.
  • Mild illness is not usually a reason to defer; defer significant acute febrile illness when appropriate and rebook with named follow-through.
  • Infection prevention layers vaccination with hand and respiratory hygiene, ventilation, cleaning, device care, PPE by risk and antimicrobial stewardship.
  • Care-home outbreak plans require early recognition, line listing, testing, health-protection advice, staffing and proportionate isolation that preserves nutrition, movement and communication.

Key red flags

Airway swelling, wheeze, hypotension or collapse after vaccination requires immediate anaphylaxis treatment and emergency transfer.

New hypoxia, confusion, hypotension or reduced urine during an outbreak requires individual sepsis and respiratory assessment.

Vesicular rash with eye involvement, widespread lesions or immunosuppression requires urgent shingles complication assessment.

Fever and rapidly progressive non-blanching rash or meningism requires emergency meningococcal treatment and notification.

Multiple linked respiratory or diarrhoeal cases in a care setting requires prompt outbreak reporting and coordinated control.

A previous true anaphylactic reaction to a vaccine component requires specialist assessment rather than routine administration or blanket avoidance.

Vaccine anaphylaxis

Rapid airway, breathing or circulation compromise after administration requires immediate intramuscular adrenaline.

Care-setting outbreak

Linked respiratory or gastrointestinal illness affects residents or staff over a compatible period.

High-consequence infection

Sepsis physiology, eye shingles, meningism or widespread infection in immune suppression requires urgent treatment.

Investigation priorities

01
Verified immunisation recordFirst step

Identify missing doses and avoid duplication.

Management branches

First-line vaccine reviewVerify, offer and complete

An older adult attends a routine, chronic-disease or care-setting review.

  1. Check verified records against the live UK schedule and current seasonal, age and clinical-risk eligibility.
  2. Assess contraindications, immune status, timing and consent and explain benefits, common reactions and important warning signs.
  3. Administer or book eligible doses, record product and batch in all relevant systems and recall for course completion.

Key medicines

Recombinant zoster vaccine (Shingrix)Give 0.5 mL intramuscularly as a two-dose course; use a six-to-12-month interval for eligible immunocompetent adults and an eight-week-to-six-month interval for eligible immunosuppressed adults under the current Green Book schedule.Confirm current eligibility and previous doses; defer significant acute febrile illness, manage bleeding risk for IM injection and use specialist advice after true component anaphylaxis.
Adult RSV vaccine in the national programmeGive one 0.5 mL intramuscular dose to adults in the current routine-age or catch-up cohort, following the current Green Book product and coadministration guidance.Verify live cohort and prior receipt because this is not currently an annual programme; use standard anaphylaxis preparedness and assess acute febrile illness and component allergy.
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Sources and review status7 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • UKHSA Green Book collectionCurrent national vaccine eligibility, products, contraindications and administration.
  • Green Book influenza chapterSeasonal influenza vaccine programme and product guidance.
  • Green Book shingles chapterShingrix cohorts, intervals and immunosuppression.
  • Green Book RSV chapterAdult RSV programme, dose and eligibility.
  • Green Book pneumococcal chapterAge and clinical-risk pneumococcal schedules.
  • UKHSA infection prevention in adult social careLayered prevention, outbreaks and proportionate precautions.
  • NICE NG15 antimicrobial stewardshipAppropriate antimicrobial selection and review.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem ·

Content changes
Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom