01OverviewDefinition, clinical context and the essential points that orientate the chapter.
Chemical injury is damage caused by contact with an acidic, alkaline or otherwise toxic substance. Household cleaners, industrial solutions, cement, solvents and incorrectly used contact-lens products can injure the surface of the eye. Concentration, temperature, duration of contact and the chemical's ability to penetrate tissue influence severity. The clinician's first useful intervention is to shorten contact time. Obtain a brief exposure account while treatment proceeds, asking another person to locate the container or safety information rather than interrupting irrigation to complete the history.
Alkalis can disrupt cell membranes and penetrate into deeper tissues; acids often produce protein coagulation that limits further penetration, although this is not a guarantee of a superficial injury. Hydrofluoric acid is an important exception and requires urgent specialist toxicology advice because fluoride can cause deep tissue and systemic effects. An explosion may combine chemical exposure with a penetrating fragment or thermal burn. Check the wider injury pattern and personal protective requirements while ensuring that time-critical eye decontamination is actually happening.
Hold the lids open gently and encourage movement of the eye so fluid reaches the exposed conjunctiva. A topical ocular anaesthetic given by a clinician can reduce blepharospasm and make flushing feasible, but looking for it must not postpone the first water. Avoid directing a forceful jet onto the cornea. Position the head to reduce contamination of the uninjured eye, protect staff from splashes and assess skin or airway exposure where relevant. Remove contact lenses promptly during irrigation when they can be reached without traumatic manipulation.
Surface pH guides ongoing washout but is not a complete measure of injury. Aim for a stable physiological, near-neutral reading using the local measurement method and comparison eye. The NHS Highland protocol checks pH at the end of irrigation, again after five minutes and, if neutral or near neutral, after twenty minutes. A pause matters because irrigant can transiently mask residual chemical. Rebound abnormality suggests persistent material or chemical release from tissues and requires renewed irrigation and inspection. No predetermined number of litres proves that decontamination is complete. The immediate minimum twenty-minute first-aid period is therefore not a universal stopping rule.
After decontamination, document visual acuity, pupils, corneal clarity, epithelial defects, conjunctival involvement and limbal perfusion. Fluorescein demonstrates areas without intact epithelium. The limbus contains cells required to renew the corneal surface; damage there predicts persistent epithelial problems. Roper–Hall and Dua classifications describe severity using different combinations of haze, limbal involvement and conjunctival injury. Record actual findings as well as any grade so that another clinician can follow change. Definitive anti-inflammatory, antimicrobial and surface-support treatment depends on this assessment and the evolution over subsequent days.
Key points
- Time to irrigation is a major modifiable determinant of damage; clean tap water is suitable when saline is not immediately available.
- Use a gentle continuous flow, protect the other eye from runoff and remove contact lenses as soon as practicable without delaying flushing.
- Irrigate for at least twenty minutes initially and continue as required until surface pH remains physiological after a pause.
- Check both eyes' surface pH when equipment is ready; reassess after irrigation has stopped briefly so the reading is not simply irrigating fluid.
- Inspect and clear retained particles from the conjunctival fornices, then irrigate again because trapped material can cause rebound alkalinity.
- Record acuity and examine the cornea and limbus after immediate decontamination; less pain does not reliably indicate a mild injury.
- Severe epithelial loss, limbal ischaemia, corneal haze or raised pressure requires specialist treatment and close follow-up.
02AetiologyUnderlying causes, associations and risk factors, with why each one matters.
Alkaline exposure
Cement, lime, ammonia and drain-cleaning products can produce deep chemical damage because alkaline substances penetrate ocular tissues and disrupt cellular membranes.
Acids and irritants
Battery fluid, cleaning agents, solvents and unsuitable contact-lens solutions have different toxic effects; concentration and contact time strongly influence the eventual injury.
Combined mechanisms
Industrial explosions and deliberate chemical assaults may also involve heat, high-velocity fragments, skin burns or inhalation injury alongside ocular surface contamination.
03PathophysiologyThe causal sequence from the underlying abnormality to symptoms and harm.
- 1Loss of epithelial barrier
Chemical toxicity kills surface cells, exposing corneal stroma and sensory nerves; the damaged barrier becomes vulnerable to infection and further inflammation.
- 2Limbal stem-cell damage
Ischaemia and cellular destruction at the corneal margin impair epithelial renewal, allowing recurrent defects, vascularisation and conjunctival growth over the cornea.
- 3Inflammatory tissue breakdown
Persistent inflammatory activity and proteolytic enzymes can degrade stromal collagen after exposure, producing thinning even when the surface chemical has been removed.
04Clinical features and red flagsSymptoms, examination findings, patterns of presentation and time-critical warnings.
Haze obscuring iris detail, a pale avascular limbus or marked acuity reduction after exposure requires urgent specialist assessment even if the patient reports less discomfort.
Painful involuntary lid closure can prevent effective washout; clinician-administered topical anaesthesia and gentle assistance may be needed to expose the surface.
Cement, lime or powder can remain beneath the lids and continue releasing chemical despite an apparently adequate initial irrigation volume.
Facial burns, cough, breathlessness or a high-energy mechanism should prompt assessment for additional injuries while eye irrigation proceeds.
05InvestigationsWhat to request, why it matters and how to interpret it.
Read from the initial assessment onwards. Tests may run in parallel in urgent care; first-line, preferred, confirmatory, definitive and gold-standard labels appear only when the chapter explicitly states them.
- 01
Surface pH during decontaminationFirst step - Why
- Determine whether continued chemical contamination requires further irrigation.
- Interpretation and limitations
- Measure without postponing the first washout and repeat after a short irrigation-free interval; a near-normal reading during fluid flow can be misleading.
- 02
Visual acuity and pupillary assessment - Why
- Establish visual function once immediate irrigation is underway or complete.
- Interpretation and limitations
- Record each eye separately and distinguish baseline impairment from new loss; do not allow a formal chart assessment to delay emergency flushing.
- 03
Fluorescein and slit-lamp examination - Why
- Map epithelial loss and identify corneal or anterior segment injury.
- Interpretation and limitations
- Document defect size, haze and inflammation; staining identifies surface loss but cannot alone predict limbal stem-cell survival or deeper injury.
- 04
Lid eversion, fornix inspection and pressure - Why
- Detect retained material and secondary pressure elevation after decontamination.
- Interpretation and limitations
- A trained examiner clears accessible particles and checks pressure when globe integrity permits; suspected penetrating injury changes the safety of manipulation and tonometry.
06Differential diagnosisRealistic alternatives and the features that help distinguish them.
Thermal ocular burn
Heat exposure can damage the lids and surface without chemical contamination; mixed injuries occur during fires, molten-metal accidents and explosions.
Mechanical abrasion
A scratch produces focal epithelial loss and pain but does not by itself explain abnormal ocular pH, limbal blanching or a corrosive exposure history.
Microbial keratitis
Corneal infection causes pain, infiltrate and epithelial breakdown; contact-lens wear and delayed presentation may complicate interpretation after a reported minor exposure.
07ManagementImmediate care, first-line treatment, alternatives and escalation.
01Immediate actionRemove the chemical without delayFirst stepA credible chemical exposure is reported or contaminated material is visible around the eye.+
- 1Start abundant gentle water or saline irrigation immediately while another team member calls for urgent assistance and obtains exposure information.
- 2Open the lids, use topical anaesthetic if promptly available, and remove accessible contact lenses during flushing without interrupting decontamination unnecessarily.
- 3Continue for at least twenty minutes initially, then use repeated surface pH and the examination to determine how much further irrigation is needed.
02Persistent contaminationFind the source of rebound pHThe ocular surface remains abnormally acidic or alkaline after an initial period of irrigation.+
- 1Resume irrigation and verify how and when the pH sample was taken, comparing the other eye where appropriate.
- 2Evert the lids and inspect the fornices for trapped particles, removing accessible material carefully with suitable equipment and then washing out again.
- 3Recheck after a pause rather than accepting the pH of flowing saline, and involve ophthalmology early when contamination persists or examination is difficult.
03Definitive assessmentTreat the injured ocular surfaceDefinitiveDecontamination is achieved but pain, reduced vision or epithelial and limbal damage remains.+
- 1Document corneal and conjunctival defects, limbal perfusion, acuity and pressure where safe, and communicate the exposure and irrigation record to ophthalmology.
- 2Arrange specialist-directed antimicrobial cover, inflammation control and lubrication; severe burns may require intensive therapy, admission or surgical surface protection.
- 3Give explicit review arrangements and warning symptoms, ensuring the patient can obtain treatment and return promptly if vision or pain worsens.
Key medicines and prescribing safety1 treatment · regimens, roles and cautions+
Proxymetacaine hydrochloride 0.5% eye drops
A clinician may instil one or two drops topically for a brief ocular procedure; repeat only according to the supervised procedural requirement.Do not delay irrigation to obtain anaesthetic, and do not supply repeated unsupervised use; prolonged topical anaesthesia can damage the cornea and mask deterioration.
08ComplicationsImportant consequences, why they occur and why they matter clinically.
Corneal melt and perforation
Progressive stromal breakdown may cause severe thinning or a full-thickness defect, threatening the structural integrity of the globe and long-term vision.
Chronic ocular surface failure
Limbal deficiency, scarring and tear-film disturbance can cause persistent defects, recurrent discomfort, corneal vascularisation and reduced optical clarity.
Secondary glaucoma and scarring
Damage to anterior segment structures can impair aqueous drainage, while conjunctival contraction may shorten the fornices and tether the eyelids to the globe.
09Monitoring and follow-upTreatment response, safety checks and longer-term review.
- Repeat pH after cessation of washout and again if symptoms or retained material suggest ongoing exposure; record the timing relative to irrigant and other drops.
- Follow epithelial closure, limbal appearance, corneal thickness and visual function because tissue damage can evolve after the chemical has been removed.
- Check pressure during specialist follow-up, recognising both injury-related elevation and pressure responses to topical corticosteroids.
- Review treatment delivery, pain control and access to urgent eye care; severe burns require a much closer schedule than a mild irritant exposure.
10Special situationsVariants, exceptions and circumstances that change the usual approach.
A white eye can be severe
Limbal blanching reflects loss of perfusion and may be more concerning than dramatic redness; absence of visible hyperaemia is not reassurance.
Neutral surface is not healed tissue
Restoring pH removes ongoing chemical exposure but cannot reverse established epithelial, stromal or intraocular damage, so examination remains necessary.
Powder acts as a reservoir
Material hidden in a conjunctival fold can sustain exposure and explain repeated abnormal readings after apparently successful washout.
Document the treatment timeline
Exposure time, first irrigation, fluid used, particle removal and repeat pH help the receiving clinician interpret severity and further decontamination needs.
11Common pitfallsFrequent interpretation and management errors.
- 01
Completing visual acuity, registration or a full chemical history before starting the first irrigation.
- 02
Stopping automatically after one bag of saline without checking the surface and considering retained particulate matter.
- 03
Attempting chemical neutralisation with an opposing acid or alkali instead of dilution and physical removal.
- 04
Prescribing topical steroid or repeated anaesthetic for an unexamined painful eye without specialist assessment and review.