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Acute severe and life-threatening asthma

Essential points for quick revision.

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Life-threatening asthma attack

Silent chest, cyanosis, poor respiratory effort, exhaustion, altered consciousness, hypotension or arrhythmia defines a life-threatening attack; saturation below 92% or peak flow below 33% adds objective danger.

Action: Call senior paediatric and intensive-care help, give high-flow oxygen to target 94–98%, administer oxygen-driven nebulised salbutamol plus ipratropium and systemic corticosteroid immediately, attach continuous monitoring and obtain blood gas without delaying treatment. Prepare controlled ventilatory support; use intravenous magnesium and further bronchodilator therapy only through the senior acute-asthma pathway. Never sedate.

Synopsis

Recognise age-specific severe and life-threatening asthma from the worst feature, start oxygen and inhaled bronchodilator immediately, add anticholinergic and systemic corticosteroid, reassess repeatedly, and escalate safely to intravenous therapy and paediatric intensive care without sedation.

  • Grade severity from the most dangerous feature. A child does not need every criterion, and falling tachycardia or respiratory rate with exhaustion is deterioration.
  • First line: give oxygen to target 94–98% and salbutamol immediately. Mild-to-moderate attacks can use a pressurised metered-dose inhaler and spacer; severe or hypoxaemic attacks use an oxygen-driven nebuliser.
  • Spacer regimen: give one salbutamol 100-microgram puff at a time with tidal breaths, repeating up to 10 puffs and reassessing; use a mask when a mouthpiece seal is unreliable.

Key red flags

Silent chest, cyanosis, poor effort, exhaustion, confusion, drowsiness, hypotension or arrhythmia is life-threatening irrespective of respiratory rate.

Investigation priorities

01
First-line: continuous clinical reassessment and oximetryFirst stepFirst line

Grade response and identify hypoxaemia or fatigue while treatment proceeds.

Management branches

ImmediateTreat while assessing

A child presents with a current asthma attack.

  1. Give oxygen for hypoxaemia and salbutamol by spacer or oxygen-driven nebuliser according to severity.
  2. Give systemic corticosteroid early and add ipratropium for severe or life-threatening disease.

Key medicines

SalbutamolSpacer: 100 micrograms per puff, one puff at a time up to 10 puffs with reassessment. Severe attack by oxygen-driven nebuliser: 2.5 mg under 5 years or 5 mg age 5 and over, repeated according to response and protocol.
PrednisoloneCommon UK acute regimen: age 2–5 years 20 mg orally once daily; age over 5 years 30–40 mg once daily, usually for at least 3 days. Verify current BNF-C, weight and local protocol.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom