01Purpose and principlesWhat the treatment does and how it fits into care.
Fluid prescribing begins with the clinical question. A shocked child needs resuscitation; a stable dehydrated child needs deficit replacement; a nil-by-mouth child needs maintenance; a child with a stoma or drain needs additional replacement. Combining these into one unlabelled rate causes under-resuscitation, overload and electrolyte error. Record current weight, clinical fluid status, input, output, losses, medicines, renal and cardiac function and the calculation for each component.
Dehydration is a syndrome, not a skin-turgor percentage. Ask about usual and current feeds, vomiting and diarrhoea frequency, urine or wet nappies, tears, thirst, fever and weight. Observe interaction, respiratory pattern and eyes; inspect mouth; assess pulses, capillary refill, skin temperature and consciousness. A recent accurate pre-illness weight gives the best deficit estimate: percentage loss equals weight lost divided by pre-illness weight × 100. Without it, use a cluster of signs and reassess response.
NICE gastroenteritis guidance groups children as no dehydration, clinical dehydration or shock. Red flags for progression include altered responsiveness, sunken eyes, tachycardia, tachypnoea, reduced skin turgor and reduced urine. Shock includes reduced consciousness, pale or mottled skin, cold extremities, weak pulses, prolonged refill and hypotension. The shock phenotype triggers ABCDE and rapid intravenous or intraosseous access; do not attempt to prove a numerical dehydration percentage first.
Oral rehydration solution exploits sodium-glucose cotransport and replaces water plus electrolytes more safely than juice, fizzy drink or plain water. For clinical dehydration, give low-osmolarity ORS 50 mL/kg over four hours in addition to maintenance, using small frequent volumes. Continue breastfeeding. If drinking is insufficient, use nasogastric administration before defaulting to IV when clinically safe. Persistent vomiting of oral and NG ORS, deterioration or shock are IV indications.
After rehydration, restart full-strength milk and normal food and encourage usual fluids. For children at increased recurrence risk, NICE suggests 5 mL/kg ORS after each large watery stool. Give parents a practical volume and syringe or cup plan and explain red flags. Antidiarrhoeal medicines are not routine treatment in young children, and fruit juice or carbonated drinks can worsen osmotic diarrhoea.
For IV resuscitation, NICE NG29 recommends a glucose-free crystalloid containing 131–154 mmol/L sodium, 10 mL/kg over less than ten minutes. Term neonates may receive 10–20 mL/kg under the neonatal recommendation. Reassess heart rate, pulses, refill, blood pressure, consciousness, urine, breathing, crackles and liver size after each aliquot. A child with persistent shock after fluid needs review of sepsis, haemorrhage, cardiogenic obstruction, adrenal crisis and critical-care support rather than automatic unlimited boluses.
Routine maintenance uses the Holliday–Segar method. A 24 kg child receives 1,000 mL for the first 10 kg, 500 mL for the next 10 and 80 mL for the remaining 4: 1,580 mL/day, about 66 mL/hour. This is an upper starting calculation for a normally hydrated stable child, not a mandatory volume. Fever, ventilation, renal impairment, oedema and high ADH states alter need, while ongoing losses are added separately.
NICE recommends initial routine maintenance with isotonic crystalloid containing 131–154 mmol/L sodium to reduce hospital-acquired hyponatraemia. Glucose need depends on age and intake. Term neonates at least 8 days old generally need isotonic fluid with 5–10% glucose; in the first seven days, sodium and glucose requirements follow postnatal adaptation and specialist judgement. Preterm neonates use neonatal protocols. Potassium is added only after checking concentration, renal function and urine output and following local standard bags.
Non-osmotic ADH secretion occurs with pain, nausea, surgery, lung or brain disease and many acute illnesses. NICE advises considering 50–80% of routine maintenance or insensible losses plus urine output when water retention risk is present. Restriction is a monitored prescription, not neglect: reassess hydration, weight, sodium, glucose, urine and losses. A child with simultaneous deficit or high-output loss needs those components replaced despite restricted baseline maintenance.
Hyponatraemia during IV therapy requires immediate volume and fluid review. Change hypotonic maintenance to isotonic and restrict when hypervolaemic or ADH-driven. Acute neurological symptoms require critical-care advice and NICE hypertonic therapy: 2 mL/kg of 2.7% sodium chloride, maximum 100 mL, over 10–15 minutes, repeat while symptoms persist under the algorithm and monitor sodium at least hourly. Fluid restriction alone is not treatment for hyponatraemic encephalopathy.
Hypernatraemic dehydration is corrected slowly to avoid cerebral oedema. NICE gastroenteritis guidance advises urgent expert input, an isotonic solution for deficit and maintenance, replacement typically over 48 hours and a sodium fall below 0.5 mmol/L/hour. Monitor neurological status, glucose, electrolytes, weight and fluid balance frequently. Do not subtract every hypernatraemic child into the standard four-hour ORS pathway without assessing severity, although ORS remains appropriate in stable clinical dehydration.
Monitor all IV therapy as a medicine. Record fluid type, additives, rate and indication, hourly input and urine or other output, 12-hour balance subtotal and at least 12-hour prescription review under NICE. Weigh when feasible. Check electrolytes and glucose before routine IV therapy except selected elective surgery and at least daily, more often during correction or high losses. Stop IV fluid as soon as adequate enteral intake is established.
Key points
- Separate four prescriptions: resuscitation restores circulation, deficit replaces prior loss, maintenance covers normal needs and replacement matches continuing abnormal loss.
- Assess dehydration from appearance, interaction, thirst, mucosa, tears, eyes, pulses, refill, breathing, urine and weight change; no single sign gives a reliable percentage.
- First-line for clinical dehydration from gastroenteritis without shock is low-osmolarity oral rehydration solution, 50 mL/kg deficit over 4 hours plus maintenance, given frequently in small amounts.
- Continue breastfeeding during oral rehydration and consider nasogastric ORS when the child cannot drink enough or vomits persistently.
- Use IV fluid for shock, deterioration despite oral or nasogastric ORS or persistent vomiting of ORS.
- NICE IV resuscitation uses 10 mL/kg glucose-free crystalloid with sodium 131–154 mmol/L over less than 10 minutes, then immediate reassessment.
- Calculate routine daily maintenance by Holliday–Segar: 100 mL/kg for the first 10 kg, 50 mL/kg for the next 10 kg and 20 mL/kg for each kg above 20.
- For hourly maintenance, the corresponding 4-2-1 rule gives 4 mL/kg/hour for the first 10 kg, 2 for the next 10 and 1 for each kg above 20.
- Initial routine IV maintenance for children uses isotonic crystalloid with sodium 131–154 mmol/L; add glucose and potassium according to age, results and clinical need.
- Restrict to about 50–80% of calculated maintenance when non-osmotic ADH and water retention are likely, then review clinically and biochemically.
- Check electrolytes and glucose at initiation and at least every 24 hours during routine IV maintenance, more often with instability, abnormal results or high losses.
- Replace ongoing gastric, diarrhoeal, stoma, drain or urinary losses separately with measured or estimated volume and appropriate electrolyte composition.
02Indications, selection and cautionsWho may benefit, who needs urgent treatment and important alternatives.
Thirst, reduced urine, dry mucosa, sunken eyes, tachycardia and reduced skin turgor without shock supports oral or nasogastric rehydration.
Altered consciousness, cold mottled skin, weak pulses, prolonged refill or hypotension requires immediate isotonic resuscitation and cause review.
Irritability, hypertonia, doughy skin or seizure with high sodium requires slow deficit correction and frequent neurological and biochemical monitoring.
Pain, nausea, postoperative state, pulmonary or brain disease increases ADH and supports restricted rather than full calculated maintenance.
Increasing work of breathing, crackles, hepatomegaly, oedema, weight gain or hypertension after fluid requires stopping and urgent reassessment.
Headache, confusion, vomiting, seizure, reduced consciousness or apnoea with falling sodium is a hypertonic-saline emergency.
03Assessment before treatmentTests and checks that guide safe selection.
Read from the initial assessment onwards. Tests may run in parallel in urgent care; first-line, preferred, confirmatory, definitive and gold-standard labels appear only when the chapter explicitly states them.
- 01
First-line: clinical hydration and ABCDEFirst stepFirst line - Why
- Distinguish stable dehydration from shock and detect alternative emergencies.
- Interpretation and limitations
- Use a cluster of signs, age-adjusted observations and trend; shock receives immediate resuscitation before detailed deficit calculation.
- 02
Current and pre-illness weight - Why
- Calculate prescriptions and quantify weight-defined deficit when reliable.
- Interpretation and limitations
- Percentage weight loss is the most objective deficit estimate, but scale and timing differences can create false precision.
- 03
Electrolytes, urea, creatinine and glucose - Why
- Identify sodium disorder, potassium need, renal injury and hypoglycaemia before or during IV therapy.
- Interpretation and limitations
- Repeat at least daily for routine therapy and much more frequently during hypernatraemia, symptomatic hyponatraemia or major losses.
- 04
Blood gas and lactate - Why
- Assess perfusion, acidosis and bicarbonate loss in an unwell child.
- Interpretation and limitations
- Improvement supports restored perfusion; persistent acidosis may reflect ongoing shock, sepsis, renal failure, DKA or hyperchloraemia.
- 05
Fluid balance and urine output - Why
- Measure response, ongoing loss and risk of overload.
- Interpretation and limitations
- Use hourly totals in unstable or IV-treated children, weigh nappies when needed and interpret oliguria with renal and perfusion context.
- 06
Cause-directed tests - Why
- Identify sepsis, DKA, obstruction, adrenal failure, renal disease or surgical abdomen.
- Interpretation and limitations
- Bilious vomiting, focal pain, altered consciousness or disproportionate shock directs testing beyond routine gastroenteritis.
04Treatment approachPreparation, options, escalation and aftercare.
01Clinical dehydrationRehydrate enterally firstFirst stepA child has dehydration without shock or another IV indication.+
- 1Give low-osmolarity ORS 50 mL/kg over four hours plus maintenance in small frequent amounts and continue breastfeeding.
- 2Use nasogastric ORS if oral intake is insufficient or vomiting persists but the child remains suitable for enteral therapy.
- 3Reassess regularly and switch to IV only for shock, deterioration or persistent failure of oral and NG treatment.
02ShockBolus and reassess physiologyCirculation is impaired through pulses, refill, skin, consciousness or blood pressure.+
- 1Call senior help, obtain IV or IO access, check glucose and send urgent electrolytes, gas and cause-directed samples.
- 2Give 10 mL/kg glucose-free isotonic crystalloid over less than ten minutes, modifying for cardiac or renal disease.
- 3EscalationReassess immediately and escalate for blood, further aliquot, vasoactive treatment or critical care according to cause and response.
03Routine IV maintenanceCalculate then individualiseA stable child cannot meet normal fluid needs enterally.+
- 1Calculate 100-50-20 mL/kg/day or 4-2-1 mL/kg/hour and separate deficit and ongoing replacement.
- 2Start an isotonic crystalloid with glucose and potassium selected from age, results and urine; use neonatal guidance where applicable.
- 3Consider 50–80% maintenance in high-ADH states and review balance, weight, electrolytes, glucose and enteral readiness at least 12-hourly.
04HypernatraemiaCorrect the deficit slowlyDehydration coexists with elevated plasma sodium.+
- 1Seek urgent expert advice and establish neurological status, reliable weight, deficit and ongoing losses.
- 2Use isotonic deficit and maintenance fluid and replace typically over 48 hours, avoiding a sodium fall of 0.5 mmol/L/hour or more.
- 3Monitor sodium, glucose, urine, weight and neurology frequently and adjust the rate to measured change.
05Symptomatic hyponatraemiaTreat cerebral symptoms with hypertonic sodiumAcute neurological symptoms occur with hyponatraemia during IV therapy.+
- 1Stop inappropriate free water, perform ABCDE and call paediatric critical care immediately.
- 2Give 2 mL/kg of 2.7% sodium chloride, maximum 100 mL, over 10–15 minutes and repeat under NICE if symptoms persist.
- 3Measure sodium at least hourly and control subsequent correction to no more than 12 mmol/L in 24 hours after symptoms resolve.
05Regimens, contraindications and interactionsTreatment details and the circumstances that modify them.
Low-osmolarity oral rehydration solution
For clinical dehydration from gastroenteritis, give 50 mL/kg for deficit replacement over 4 hours plus maintenance fluid, in small frequent volumes; continue breastfeeding and use nasogastric administration if oral intake is insufficient and IV criteria are absent.Make up exactly as the packet directs; over-concentration causes hypernatraemia. Do not use juice, fizzy drink or homemade salt mixtures as equivalents. Reassess frequently and switch to IV treatment for shock, deterioration or persistent vomiting despite oral or NG delivery.
Isotonic crystalloid resuscitation
Give 10 mL/kg of a glucose-free crystalloid containing 131–154 mmol/L sodium intravenously or intraosseously over less than 10 minutes for shock, then reassess before any further bolus; term neonates may require 10–20 mL/kg under neonatal guidance.Use smaller aliquots in cardiac or renal disease, use blood early in haemorrhage and monitor for crackles, hepatomegaly and worsening breathing. Do not use this generic pathway for DKA, severe malnutrition or other condition-specific fluid states.
Hypertonic sodium for acute symptomatic hyponatraemia
Give 2 mL/kg of 2.7% sodium chloride intravenously, maximum 100 mL, over 10–15 minutes; repeat a second dose if neurological symptoms persist and consider a third after checking sodium under the NICE critical-care pathway.Use senior and critical-care supervision, a secure line and at least hourly sodium measurements. After symptoms resolve, keep total sodium rise within 12 mmol/L over 24 hours and do not substitute fluid restriction alone for acute neurological treatment.
06Complications, monitoring and follow-upAdverse effects, response and longer-term review.
- During shock, reassess heart rate, pulses, refill, pressure, consciousness, breathing and liver size after every 10 mL/kg aliquot.
- During IV therapy, chart input and urine, stool, stoma, gastric and drain output hourly when clinically unstable, with running and 12-hour totals.
- Review clinical hydration, weight, oedema, prescription and possibility of oral or enteral fluid at least every 12 hours.
- Measure electrolytes and glucose at initiation and at least daily for routine maintenance, using shorter intervals for abnormalities and large losses.
- In hypernatraemia, monitor sodium frequently and keep the fall below 0.5 mmol/L/hour; in treated acute hyponatraemia, measure at least hourly initially.
- Stop or reduce IV fluid promptly when enteral intake, urine, weight or examination shows that the original indication has changed.
07Special situationsVariants, exceptions and circumstances that change the usual approach.
Maintenance is not resuscitation
A maintenance rate cannot restore shocked circulation, while a resuscitation bolus continued as maintenance rapidly causes overload.
ORS is active therapy
Its paired glucose and sodium composition drives absorption; plain water and juice do not reproduce this physiology.
The formula is a starting point
Holliday–Segar estimates normal need, then illness, ADH, organ function, deficit and losses determine the actual prescription.
Potassium waits for evidence
Check plasma potassium, kidney function and urine output before adding it, and use a standard concentration and controlled infusion.
Sodium correction has direction and speed
Both a rapid fall in hypernatraemia and an excessive rise after hyponatraemia can cause severe neurological injury.
Weight is a fluid observation
Serial weight can reveal deficit recovery or accumulating overload more sensitively than an imprecise balance chart.
08Common pitfallsFrequent interpretation and management errors.
- 01
Do not prescribe one total fluid rate without separating resuscitation, deficit, maintenance and ongoing losses.
- 02
Do not use skin turgor alone to assign a dehydration percentage.
- 03
Do not give juice, fizzy drink or plain water as equivalent treatment for clinical gastroenteritis dehydration.
- 04
Do not continue oral rehydration alone in shock or deterioration.
- 05
Do not repeat boluses without checking perfusion response and overload.
- 06
Do not use hypotonic fluid routinely for inpatient maintenance.
- 07
Do not add potassium before checking renal function, plasma potassium and urine output.
- 08
Do not correct hypernatraemia rapidly or manage symptomatic hyponatraemia by restriction alone.
- 09
Do not apply the generic pathway unchanged to DKA, neonates, severe malnutrition, burns, renal or cardiac failure.