Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
2 min synopsisUK scopeSources checked 27 Aug 2026Clinical review pending
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Neurological signs or glucose below 1.0 mmol/L
Seizures, reduced consciousness, apnoea, marked hypotonia or any blood glucose below 1.0 mmol/L requires urgent intravenous glucose and neonatal review, while other causes of illness are assessed.
Action: Stabilise airway, breathing, circulation and temperature; obtain an accurate glucose and critical blood samples if this does not delay treatment. Establish IV access, give 10% glucose 2.5 mL/kg over 5 minutes and start 10% glucose at 60 mL/kg/day under the BAPM term-infant pathway, then recheck glucose after 30 minutes and titrate through a neonatal protocol. Use buccal 40% dextrose gel as a bridge while obtaining access, not as definitive treatment for neurological signs.
Synopsis
Identify newborns at risk, support feeding and metabolic adaptation, interpret glucose within the BAPM operational-threshold framework, and treat symptomatic, severe or persistent hypoglycaemia without delaying investigation.
Screen only babies with recognised risk or abnormal signs; routine testing of healthy term babies without risk can disrupt feeding and cause unnecessary treatment.
Risk includes maternal diabetes, beta-blocker exposure, fetal growth restriction, birth weight below the 2nd centile, macrosomia, hypothermia and significant perinatal illness.
Feed an at-risk well baby within the first hour, support skin-to-skin contact and check blood glucose before the second feed at 2–4 hours of age.
Key red flags
Seizures, altered consciousness, apnoea, cyanosis, marked hypotonia or abnormal feeding with low glucose requires emergency IV treatment and investigation.
Investigation priorities
01
First-line: accurate blood glucose measurementFirst stepFirst line
Confirm hypoglycaemia and guide time-critical treatment.
Management branches
RiskPrevent and screen
A term baby is well but has a recognised hypoglycaemia risk.
Keep warm and in skin-to-skin contact and feed within 1 hour.
Measure glucose before the second feed at 2–4 hours and assess feeding directly.
Key medicines
Dextrose 40% oral gel200 mg/kg, equivalent to 0.5 mL/kg, massaged into the buccal mucosa and followed immediately by an effective feed. Repeat only within the current BAPM and local pathway after reassessment.
Glucose 10% intravenousUnder the BAPM term pathway for glucose below 1.0 mmol/L or abnormal signs, give 2.5 mL/kg IV over 5 minutes, then start 60 mL/kg/day by infusion and recheck glucose after 30 minutes. Titrate glucose infusion rate through the neonatal protocol.
National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.