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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
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Weight-based prescribing and dose checking

Essential points for quick revision.

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Suspected tenfold dosing error

A decimal, unit, weight or concentration error can produce severe toxicity before symptoms develop.

Action: Stop or withhold the medicine, preserve the prescription, container and administration device and assess ABCDE. Confirm the child, current weight, substance, concentration, intended dose, actual amount, route and time. Contact paediatric pharmacy, the National Poisons Information Service through TOXBASE and senior paediatrics urgently as appropriate; obtain drug-specific tests and antidote without waiting for symptoms when indicated. Report the incident and check whether further scheduled doses or other patients are affected.

Synopsis

Calculate, prescribe, dispense and administer paediatric medicines safely using current weight, age, indication, formulation, organ function, dose ceilings and independent verification.

  • Use the current measured weight in kilograms and record date, time and context; kilograms belong visibly on both the observation and prescribing record.
  • First-line UK dose reference is the current BNFC monograph for the exact indication, route, age and formulation, supplemented only by clearly governed specialist guidance.
  • Write the formula before calculating: dose per administration equals prescribed mg/kg/dose multiplied by weight in kg.

Key red flags

A calculated dose above the BNFC age or adult maximum, or outside the local electronic hard limit, must be resolved before administration rather than accepted because the arithmetic is correct.

Investigation priorities

01
First-line: current measured weightFirst stepFirst line

Provide the denominator for dose and fluid calculations.

02
First-line: BNFC monograph and indicationFirst line

Identify the authoritative age, route, indication, interval and maximum.

Management branches

Routine weight-based doseSource, calculate, cap and convert

A medicine is prescribed in mg/kg or micrograms/kg.

  1. Verify patient, current kg weight, indication, route, age band and the current BNFC dose expression.
  2. Calculate the dose with written units, divide daily doses correctly and apply single and daily maxima.

Key medicines

Intramuscular adrenaline for anaphylaxisFor children, give 10 micrograms/kg intramuscularly using 1 mg/mL adrenaline into the anterolateral thigh, with a maximum single dose of 500 micrograms; repeat after 5 minutes if airway, breathing or circulation compromise persists.
Intravenous paracetamol calculation exampleFor a child above 10 kg without specific risk factors, a common product regimen is 15 mg/kg intravenously per dose every 4 to 6 hours, no more than 4 doses and 60 mg/kg in 24 hours, capped at 3 g daily below 50 kg; verify the current BNFC and product age and weight band before prescribing.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom