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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Anxiety and panic with breathlessness

Palliative and end-of-life care · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Panic symptoms with possible physiological crisis

Chest pain, syncope, cyanosis, stridor, unilateral chest signs, fever, haemoptysis, exhaustion or altered consciousness cannot be attributed to panic without urgent assessment.

Action: Use ABCDE assessment and treat hypoxaemia, bronchospasm, embolism, pneumothorax, infection, arrhythmia or opioid toxicity as indicated. Stay calm and coach paced breathing in parallel; once immediate danger is addressed, assess panic, capacity, suicidal risk and the person's agreed escalation plan.

Synopsis

Recognise the reciprocal breathlessness-panic cycle without overlooking respiratory emergencies, teach immediate recovery skills, address illness understanding and avoidance, and use psychological or pharmacological treatment according to onset, goals and respiratory safety.

  • Validate the sensation without assuming its cause: panic can intensify breathlessness, and respiratory pathology can trigger genuine panic simultaneously.
  • First-line crisis care is presence, upright supported posture, cool facial airflow, one calm speaker and a slow exhalation-focused breathing pattern.
  • Use short grounding prompts: name what is happening, orient to the room, relax shoulders and match activity to a safe recovery position.
  • After recovery, map triggers, thoughts, bodily sensations, behaviour, duration, rescue use and how carers respond; identify what differs from medical emergencies.
  • Breathing retraining, cognitive behavioural strategies, pulmonary rehabilitation, pacing and graded re-engagement are first-line continuing treatments.
  • A low-dose opioid may treat refractory breathlessness, not panic itself; an anxiolytic may address severe panic, not hypoxaemia or obstruction.
  • Lorazepam can be used as carefully prescribed rescue for severe recurrent anxiety when non-drug measures fail, but respiratory and dependence risks require review.
  • An SSRI can treat persistent panic or anxiety over weeks; explain initial activation, interactions and delayed benefit and provide follow-up.
  • The gold-standard plan teaches the patient and carer how to distinguish expected episodes from red flags and specifies techniques, medicines, call route and escalation ceiling.

Key red flags

A first or changed panic-like episode with hypoxaemia, focal signs, pleuritic pain, haemoptysis or syncope requires urgent cardiopulmonary evaluation.

Falling respiratory effort, drowsiness or carbon-dioxide retention is respiratory failure, not resolution of anxiety.

Suicidal intent, inability to remain safe, severe depression or requests to hasten death requires direct same-day risk assessment.

Benzodiazepine plus opioid, alcohol, gabapentinoid or hypercapnic lung disease materially increases sedation and respiratory risk.

Increasing unsupervised rescue use, lost tablets or demands for early supply may indicate uncontrolled symptoms, dependence, misuse or unsafe caregiver administration.

A relative controlling medication or preventing private discussion raises coercion and safeguarding concerns.

Sedative accumulation

Slurred speech, unsteady gait, prolonged sleep and slowed breathing after rescue use indicates medicine harm rather than successful calming.

Investigation priorities

01
First-line episode safety assessmentFirst stepFirst line

Check airway, respiratory rate and effort, saturation, pulse, pressure, temperature, consciousness, chest and relevant embolic or cardiac features.

Management branches

Typical panic crisisReduce threat and restore efficient breathing

A familiar breathlessness-panic episode occurs without new emergency features.

  1. Stay with the patient, use one calm speaker, supported posture and facial airflow and guide a gentle prolonged exhalation without demanding deep breaths.
  2. Name and validate the fear, use grounding and administer only a pre-agreed patient-specific rescue when the non-drug sequence is insufficient.
  3. After recovery, record trigger, duration and rescue effect and practise the plan again with caregiver adjustments rather than treating the event as failure.

Key medicines

Lorazepam rescue for severe panicUse 500 micrograms orally or sublingually as a patient-specific as-needed dose under the local palliative protocol, with a written minimum interval and maximum action plan; lower exposure may be needed in frailty or hepatic impairment.Not a treatment for hypoxaemia or obstruction; opioids, alcohol, gabapentinoids, hypercapnia and liver dysfunction increase sedation, falls, delirium, dependence and respiratory depression.
Sertraline for persistent panic or anxietyStart 25 mg orally once daily when sensitivity or frailty warrants, increasing to 50 mg once daily after about one week if tolerated, with later BNF-guided titration and review.Explain delayed benefit and possible early activation; monitor gastrointestinal effects, bleeding, hyponatraemia, serotonin interactions, mood and withdrawal and reduce dose in hepatic impairment.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE CG113 anxiety and panic disorderPanic formulation, psychological treatment, antidepressant choice and benzodiazepine limitations.
  • NICE NG115 COPD recommendationsBreathing techniques, pulmonary rehabilitation, oxygen and advanced respiratory care.
  • NICE NG31 care of dying adultsBreathlessness, anxiety, non-drug measures and individual medicine assessment.
  • GMC treatment towards end of lifeGoal-concordant emergency treatment, treatment limits and continuing symptom care.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom