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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Cough and haemoptysis in advanced disease

Palliative and end-of-life care · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Life-threatening haemoptysis

Rapid pulmonary bleeding threatens death through airway flooding and asphyxia as well as blood loss; the witnessed volume may underestimate danger.

Action: Call emergency help within the agreed ceiling, stay with the patient, position the bleeding lung down when known, use dark towels and clear visible blood from the mouth without deep blind suction. Give prepared rapid-route anxiolytic only if immediately available and time permits; presence and calm communication must not be delayed by searching for medicines.

Synopsis

Assess cough and haemoptysis by mechanism and bleeding risk, treat reversible causes, use proportionate antitussive and tumour-directed therapy, and prepare a simple presence-led plan for foreseeable catastrophic pulmonary haemorrhage.

  • Ask whether blood truly came from the lower respiratory tract, then assess airway, breathing, circulation and trajectory rather than relying on volume alone.
  • First-line cough assessment defines dry or productive, triggers, timing, aspiration, reflux, medicines, infection, obstruction and impact on sleep, speech and eating.
  • Treat the cause when useful: antibiotic, bronchodilator, reflux care, drainage, airway clearance, bronchoscopy, embolisation, radiotherapy or anticoagulant review may outperform cough suppression.
  • Simple measures include upright position, hydration or mouth care, avoiding triggers, honey where safe, humidification or saline for selected thick secretion and speech-therapy techniques.
  • For dry distressing cough, an opioid antitussive can be tried at a low dose after current opioid exposure and respiratory safety are reviewed.
  • For recurrent haemoptysis, CT angiography, bronchoscopy and bronchial-artery embolisation are considered according to stability, source and goals.
  • Palliative radiotherapy can control tumour-related haemoptysis; benefit, timing and attendance burden require oncology assessment.
  • Catastrophic planning prioritises staying with the person, dark absorbent towels, known-side-down positioning and a simple call route; medicine may not act before death.
  • The gold-standard record separates minor bleed treatment from catastrophic response and states anticoagulant decisions, escalation ceiling, rescue route and family communication.

Key red flags

Any haemoptysis with airway compromise, hypoxaemia, haemodynamic instability or rapidly accumulating blood is an emergency regardless of measured volume.

A small sentinel bleed in central lung tumour, cavitation, prior radiotherapy or vascular invasion may precede catastrophic haemorrhage.

New pleuritic pain, tachycardia, syncope or leg swelling suggests pulmonary embolism and requires urgent goal-concordant investigation.

Fever, purulent sputum, focal signs or neutropenia suggests infection and can worsen both cough and bleeding.

Stridor, monophonic wheeze, postural cough or recurrent collapse suggests central obstruction, fistula or aspiration needing specialist airway assessment.

Tranexamic acid can increase thrombosis risk and requires renal reduction; visible urinary-tract bleeding raises concern for ureteric clot obstruction.

Sedating antitussives combined with opioids, benzodiazepines or respiratory failure can impair ventilation and secretion clearance.

Airway-threatening haemorrhage

Rapid blood flow, inability to clear clot, falling oxygenation or respiratory distress defines a life-threatening event regardless of volume.

Investigation priorities

01
First-line source and stability assessmentFirst stepFirst line

Confirm likely respiratory blood, quantify rate and recurrence and assess airway, ventilation, oxygenation, circulation and known bleeding risk.

Management branches

Cough managementTreat mechanism before suppressing reflex

Cough is distressing, persistent or interfering with sleep, speech, eating or treatment.

  1. Characterise dry or productive pattern, aspiration, reflux, medicines, airway and infection and identify red flags or protective clearance need.
  2. Treat the cause and use position, hydration, airflow, swallow and physiotherapy measures before selecting a low-dose antitussive for a dry refractory cough.
  3. Review frequency, sleep, sputum clearance, alertness and breathing and stop suppression that causes retention or no meaningful benefit.

Key medicines

Immediate-release morphine for refractory dry coughIn an opioid-naive adult, a specialist palliative protocol may use 2.5 mg oral immediate-release morphine as needed or at a defined interval and titrate cautiously; calculate from current exposure when already opioid treated and use a renal-appropriate alternative when needed.Monitor sedation, breathing, secretion retention, nausea and constipation; avoid stacking with codeine or other opioids and seek advice in renal or hepatic impairment.
Codeine for selected dry coughA typical adult antitussive dose is 15 to 30 mg orally every 4 to 6 hours as required under the BNF, with the lowest effective exposure and a short response review.CYP2D6 response is variable; constipation, sedation, dependence and respiratory depression occur, and renal impairment or concurrent opioid therapy makes it a poor choice.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • Scottish palliative bleeding guidelineHaemorrhage risk assessment, anticipatory planning and catastrophic bleed management.
  • UKONS acute oncology guidelinesInitial assessment and escalation of haemoptysis and other acute oncological complications.
  • BNF cough preparations summaryAntitussive choices, doses, cautions and limited role in productive cough.
  • RCR radiotherapy dose fractionationPalliative radiotherapy regimens for tumour bleeding and thoracic symptoms.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom