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Principles of cancer and non-cancer pain assessment

Essential points for quick revision.

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Pain signalling structural emergency

New severe pain may indicate metastatic spinal cord compression, pathological fracture, acute abdomen, ischaemia, infection, raised intracranial pressure or another time-critical cause.

Action: Assess ABCDE and relieve pain while performing focused neurological, vascular and musculoskeletal examination. Immobilise an unstable limb or spine when indicated and activate the appropriate acute oncology, surgical or emergency pathway; analgesia must not be withheld to preserve diagnostic signs.

Synopsis

Recognise pain as a multidimensional clinical presentation, identify emergencies and reversible causes, formulate nociceptive, neuropathic and contextual mechanisms, and measure treatment against function and goals rather than intensity alone.

  • Pain is whatever the patient reports, but assessment must also identify mechanism, cause, emergency features, functional effect and safe treatment options.
  • First-line history uses site, onset, quality, radiation, severity, timing, triggers, associated features, previous response and impact on sleep, movement and roles.
  • Classify each pain as somatic, visceral, neuropathic or mixed; one person may need a separate formulation for several concurrent pains.

Key red flags

Back pain with new weakness, sensory change, gait deterioration or bladder or bowel dysfunction requires emergency metastatic spinal cord compression assessment.

Toxicity masquerading as pain

Myoclonus, hallucinations, allodynia, diffuse pain and sedation during escalating opioid exposure should prompt toxicity review.

Investigation priorities

01
First-line multidimensional pain historyFirst stepFirst line

Define each pain's site, time course, quality, severity, triggers, associated features, response, meaning and functional impact.

Management branches

Initial assessmentFormulate before escalating analgesia

A patient reports new, changed or inadequately controlled pain.

  1. Identify immediate red flags, give proportionate relief and describe each pain's timing, quality, triggers, functional effect and associated features.
  2. Examine the relevant systems, reconcile all medicines and organ function and use targeted tests only where results could change management.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom