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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
RapidMLAMSRAFoundationGP

Core and biological symptoms of depression

Essential points for quick revision.

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Severe depression with immediate danger

Current suicidal intent, refusal of essential food or fluids, depressive stupor, catatonia, psychotic commands or inability to care for dependants requires urgent assessment before routine symptom counting.

Action: Address ABCDE and physical consequences, remove immediate means, arrange proportionate observation and obtain same-day specialist mental-health assessment. Assess decision-specific capacity, protect children or vulnerable adults and use voluntary care or the correct jurisdiction-specific legal route according to need.

Synopsis

Recognise a depressive syndrome through sustained mood, interest, energy, cognition and biological change, assess suicide and psychosis directly, and distinguish clinically significant illness from ordinary sadness without reducing diagnosis to a questionnaire score.

  • Core depressive experiences include sustained low mood, reduced interest or pleasure and reduced energy, but the person's language may emphasise emptiness, irritability, numbness or inability to care.
  • Biological or somatic changes include sleep disturbance, appetite or weight change, psychomotor slowing or agitation, reduced libido, fatigue and sometimes early-morning or diurnal worsening.
  • Cognitive features include impaired concentration and decision making, guilt, worthlessness, hopelessness, negative expectations and recurrent thoughts of death.

Key red flags

Suicidal planning, rehearsal, available means, recent self-harm, severe hopelessness or the belief that others are better off after the person's death requires an immediate scenario-based formulation.

Investigation priorities

01
Collaborative symptom and duration historyFirst step

Establish mood, interest, energy, cognition, biological change, persistence and previous baseline.

Management branches

Initial assessmentDefine syndrome, function and danger

A person reports persistent low mood, reduced motivation, fatigue or loss of interest.

  1. Establish core, cognitive and biological symptoms, duration, baseline and concrete functional consequences using the person's own language.
  2. Ask directly about suicide, self-harm, psychosis, catatonia, mania, substances, physical illness and dependants.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom