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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Postnatal depression

Psychiatry · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Postnatal danger or possible psychosis

Suicidal intent, a plan to harm the baby, command hallucinations, delusions involving the infant, severe agitation, profound self-neglect, stupor, mania or rapidly developing confusion requires emergency assessment; suspected postpartum psychosis needs specialist assessment within four hours of referral.

Action: Keep the parent and baby safe with continuous responsible support, ask directly about intent, beliefs, voices, sleep and ability to provide care, involve emergency mental-health and paediatric or maternity services as indicated, and arrange safe transport rather than leaving the family to navigate referral alone.

Synopsis

Recognise depression across the first postnatal year, distinguish transient emotional change from severe illness and psychosis, assess parent and infant safety, and deliver timely psychological, social and medication support.

  • Postnatal depression may begin during pregnancy, soon after birth or later in the first year; asking only at the six-to-eight-week check misses cases.
  • Baby blues are common and usually resolve within two weeks; persistence, worsening or substantial impairment warrants assessment for depression.
  • Look for low mood, loss of pleasure, guilt, hopelessness, anxiety, irritability, impaired concentration, sleep difficulty despite opportunity and difficulty feeling connected to the baby.
  • Ask about suicide, self-harm, thoughts involving the infant, psychosis, mania, substances, domestic abuse, support and the practical capacity to provide care.
  • Unwanted, distressing, resisted intrusive harm thoughts can occur without intent; explore them carefully instead of either dismissing them or assuming dangerousness.
  • Use facilitated self-help for persistent subthreshold or mild-to-moderate symptoms and consider high-intensity therapy, antidepressant treatment or combination care for moderate or severe depression.
  • Treat feeding as a shared decision: discuss maternal benefit, infant exposure, consequences of switching and the effect of night feeding on recovery and sleep.
  • Sertraline or paroxetine are preferred SSRIs during breastfeeding for a full-term healthy infant when a new choice is required, but do not switch an effective SSRI solely for breastfeeding in that setting.
  • Review the parent-infant relationship through interaction, emotional availability and practical care, offering dyadic help without blaming the parent.
  • Create an explicit safety and follow-up plan that includes the partner or chosen supporter with consent and names out-of-hours contacts.

Key red flags

A specific suicide plan, recent attempt, violent command hallucination or expressed intention to harm the infant requires immediate emergency action.

New elation, reduced need for sleep, grandiosity, paranoia, perplexity or rapidly fluctuating behaviour after birth suggests postpartum psychosis or mania, not routine depression.

Inability to feed oneself or the baby, severe dehydration, near-total insomnia or loss of basic care indicates severe illness and urgent need.

Fever, severe headache, seizure, focal neurology, heavy bleeding, chest pain, breathlessness or collapse needs simultaneous physical and obstetric emergency assessment.

Bruising, controlling behaviour, fear of going home, unsafe sleeping conditions or concerns about another caregiver require safeguarding and domestic-abuse pathways.

Investigation priorities

01
Full postnatal mental-state assessmentFirst step

Define depressive symptoms, anxiety, intrusive experiences, psychosis, mania, cognition, sleep opportunity, function and treatment history.

Management branches

Initial assessmentSeparate depression from immediate danger

Low mood, anxiety, difficulty coping or bonding concern emerges during the first year after birth.

  1. Characterise symptoms, timing, birth experience, sleep opportunity, physical recovery, support, feeding and functional change.
  2. Ask directly about suicide, self-harm, thoughts about the infant, mania, psychosis, substances, abuse and who can keep parent and baby safe.
  3. Use emergency assessment for acute risk or possible postpartum psychosis; otherwise agree diagnosis, treatment setting and rapid access if symptoms escalate.
Antidepressant careChoose treatment with infant context

An antidepressant is preferred, previously effective or clinically needed during breastfeeding.

  1. Review prior response, current medicine, infant gestation and health, feeding pattern, interactions and the consequences of switching or stopping.
  2. When initiating an SSRI for a full-term healthy breastfed infant, consider sertraline or paroxetine as SPS-preferred options; retain an effective existing SSRI when appropriate.
  3. Monitor maternal activation and suicidality plus infant feeding, alertness, gastrointestinal symptoms and weight, escalating concerns rather than abandoning treatment without review.

Key medicines

Sertraline during breastfeedingFor adult depression, start sertraline 50 mg by mouth once daily. If needed, raise by 50 mg increments at intervals of at least one week to no more than 200 mg daily; continue at the lowest effective dose and reduce gradually when eventually stopping.Review activation, suicidal change, bipolarity, serotonergic interactions, hyponatraemia and bleeding. Observe the infant for agitation, restlessness, insomnia, drowsiness, diarrhoea, poor feeding and adequate weight gain; seek specialist advice for prematurity, illness, unusual symptoms or multiple maternal medicines.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE CG192 perinatal guidancePostnatal identification, depression treatment, emergency psychosis referral and mother-baby care.
  • NHS postnatal depressionSymptoms, baby-blues distinction, routes to care and recovery information.
  • SPS SSRIs in breastfeedingPreferred agents and infant observations for full-term healthy babies.
  • NICE NG194 postnatal careRepeated postnatal assessment, emotional wellbeing and attachment support.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom