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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Stepwise maintenance treatment of adult asthma

Respiratory · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

RapidFull
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Escalate

A maintenance plan does not manage an acute severe attack. Marked breathlessness, inability to speak normally, PEF at or below 50% best/predicted, hypoxaemia, exhaustion or poor response to the person's reliever plan requires same-day emergency assessment; call 999 for life-threatening features.

Synopsis

Use the current UK ICS/formoterol-first pathway, fix modifiable causes before stepping up, and escalate or step down with explicit review points, device-specific doses and steroid-safety checks.

  • Confirm asthma objectively where possible and check inhaler technique, adherence, smoking, triggers and comorbidity before every step up.
  • Adults and people aged 12 or over with infrequent symptoms should be offered low-dose ICS/formoterol as-needed anti-inflammatory reliever (AIR), not SABA alone.
  • If newly diagnosed and highly symptomatic, or presenting with a severe exacerbation, start low-dose maintenance-and-reliever therapy (MART) rather than AIR alone.
  • If AIR is insufficient, move to low-dose MART; if low-dose MART remains insufficient after correction of basics, trial moderate-dose MART for 8-12 weeks.
  • If uncontrolled on moderate-dose MART, refer to an asthma specialist rather than repeatedly adding unsupervised medicines or oral steroid courses.
  • AIR and MART require a fast-acting formoterol combination; not every ICS/LABA inhaler can be used as a reliever.
  • Prescribe by brand/device and state maintenance, as-needed and maximum doses because nominal and delivered strengths differ.
  • Every patient needs a personalised action plan covering daily treatment, deterioration thresholds, attack instructions and urgent help.
  • Review 8-12 weeks after starting or changing treatment; consider step-down after sustained control, usually reducing ICS exposure gradually with close review.
  • Track SABA and oral corticosteroid exposure even in people using AIR/MART; repeated rescue use or steroid courses signal excess risk and require reassessment.

Key red flags

High future risk

Previous ICU/intubation, recent hospital attendance, repeated oral steroids, poor adherence, excess SABA collection, psychosocial barriers, food allergy or low lung function can confer risk even when daily symptoms seem modest.

Investigation priorities

01
Asthma Control Test/Questionnaire plus attack historyFirst step

Measure current impairment and future risk separately.

Management branches

Preferred pathwayAIR to MART to specialist

Confirmed asthma in an adult or person aged 12 years or over.

  1. 1. Infrequent symptoms: offer low-dose ICS/formoterol as needed (AIR), teach device use and give a personalised action plan. Do not add routine SABA to an AIR/MART plan unless a specialist-defined exception applies.
  2. 2. If AIR does not control asthma, or at diagnosis symptoms are highly symptomatic/recently exacerbating, use low-dose MART: scheduled low-dose ICS/formoterol plus the same inhaler when needed.
  3. 3. If uncontrolled, first correct technique, adherence, exposures and comorbidity; then trial moderate-dose MART for 8-12 weeks and review benefit/adverse effects.
  4. 4. If still uncontrolled on moderate-dose MART, refer for specialist assessment. Do not drift into repeated oral steroid bursts without a diagnosis/risk and steroid-sparing review.

Key medicines

Budesonide/formoterol low-dose AIR (example device)Delivered 160/4.5 micrograms per inhalation: 1 inhalation when needed; if symptoms persist after a few minutes take 1 more. Maximum 6 on one occasion; more than 8 in a day is not normally needed and up to 12/day is only for a limited period under the SmPC.Use only a product licensed/specified for AIR. Seek urgent help if it does not relieve worsening symptoms; frequent doses require review. Rinse mouth after regular exposure and monitor tremor, palpitations and thrush.
Budesonide/formoterol low-dose MART (example device)Delivered 160/4.5 micrograms: commonly 1 inhalation twice daily (or 2 once daily) plus 1 inhalation as needed; total above 8/day is not normally needed, absolute product maximum 12/day for a limited period.Exact dose depends on device and prescribed ICS category. Do not use a slow-onset LABA combination as reliever and do not duplicate LABA across inhalers.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • NICE NG245 recommendationsCurrent UK AIR/MART stepwise pathway and review principles.
  • NICE NG245 Algorithm C for people aged 12 and overStep-up sequence and specialist referral.
  • MHRA SABA overuse safety updateNo SABA monotherapy and overuse risk.
  • DuoResp Spiromax 160/4.5 SmPCExample product-specific AIR/MART doses and maximums.
  • Spiriva Respimat SmPCLicensed tiotropium asthma add-on dose.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom