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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.

Avascular necrosis

Rheumatology · UK scope · Sources checked 27 Aug 2026 · Clinical review pending

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Fracture, dislocation or septic mimic

Severe acute hip pain after trauma, deformity, inability to bear weight, a hot joint with systemic illness or neurovascular compromise may represent fracture, dislocation or infection rather than chronic osteonecrosis.

Action: Give analgesia, minimise movement, document distal neurovascular status and arrange urgent radiography and orthopaedic assessment; use the septic-joint pathway when infection is plausible and never delay dislocation reduction for elective MRI.

Synopsis

Recognise osteonecrosis before subchondral collapse, identify traumatic and systemic causes, use MRI when radiographs are unrevealing, protect the joint while staging is completed, and refer while joint-preserving options remain possible.

  • Suspect femoral-head osteonecrosis in progressive groin or buttock pain with painful internal rotation, especially after glucocorticoids, heavy alcohol, trauma, sickle-cell disease, lupus or transplantation.
  • Obtain anteroposterior pelvis and lateral hip radiographs first, while recognising that early osteonecrosis can be radiographically invisible.
  • MRI without contrast is the preferred confirmatory test when suspicion persists and sensitively defines lesion location, size, bilateral disease and early subchondral fracture.
  • A crescent sign represents subchondral fracture; femoral-head flattening and joint-space change indicate collapse and secondary arthritis.
  • Refer promptly to hip-preservation or orthopaedic care before collapse; core decompression, sometimes with graft or augmentation, is considered for selected symptomatic early lesions.
  • After collapse, joint-preserving procedures are less predictable and total hip replacement usually provides the most reliable definitive relief for advanced symptomatic disease.
  • Reduce modifiable exposure but never stop long-term glucocorticoids abruptly; coordinate the lowest effective dose or steroid-sparing treatment with the responsible team.
  • No established routine medicine reverses osteonecrosis; analgesia and protected loading control symptoms while stage-specific surgical decisions are made.

Key red flags

A shortened or rotated limb, major trauma or sudden inability to bear weight requires urgent exclusion of femoral-neck fracture or hip dislocation.

Fever, marked warmth, severe pain with passive movement or immunosuppression requires urgent aspiration and treatment planning for septic arthritis.

Night pain, weight loss, a mass, cytopenias or a destructive lesion suggests malignancy, infection or marrow disease rather than isolated osteonecrosis.

New bilateral hip pain during high-dose glucocorticoids, after transplantation or with sickle-cell disease merits early MRI because symptoms can precede radiographic change.

Investigation priorities

01
First-line AP pelvis and lateral hipFirst stepFirst line

Exclude fracture, advanced osteoarthritis and destruction while identifying sclerosis, cysts, crescent fracture or flattening.

02
Preferred confirmatory MRIPreferred

Detect early necrotic bone, define lesion size and weight-bearing location, assess subchondral integrity and examine both hips.

Management branches

First-line recognitionImage risk-associated mechanical pain

Groin or joint pain and restricted movement occur after a recognised vascular insult or systemic exposure.

  1. Exclude fracture, dislocation and septic arthritis from acuity, observations and examination, then document glucocorticoid, alcohol, trauma, haematological and systemic risks.
  2. Obtain orthogonal radiographs and proceed to MRI of both hips when films are normal or equivocal but clinical probability remains meaningful.
  3. Stage by collapse, size and load-bearing location, assess other high-risk joints and refer before advising prolonged observation.
  4. Provide a walking aid, adapt high-impact loading and maintain safe conditioning while diagnosis and surgical strategy are completed.

Key medicines

NaproxenUse 250–500 mg orally twice daily with food for the shortest period needed while definitive assessment proceeds; add gastroprotection when indicated and stop without functional benefit.Avoid active gastrointestinal bleeding, severe kidney impairment and decompensated heart failure; assess anticoagulants and blood pressure. Avoid from 20 weeks of pregnancy unless necessary and from 28 weeks entirely.
ParacetamolTake 500–1,000 mg orally when needed at intervals of at least four hours, never exceeding 4,000 mg in 24 hours in a suitable adult; lower the ceiling for low weight, malnutrition, frailty or liver disease.Check combination products and alcohol or liver risk; regular treatment should be reviewed rather than continued automatically when pain remains severe or function worsens.
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Sources and review status4 sources · checked 27 Aug 2026 · clinical review pending+
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

  • ACR Appropriateness Criteria OsteonecrosisImaging sequence, MRI selection and staging.
  • AAOS Osteonecrosis of the hipRisk, natural history and stage-related surgery.
  • NICE NG38 Fractures recommendationsImmediate fracture assessment, analgesia and imaging principles.
  • MHRA systemic corticosteroid safety adviceAdrenal suppression, steroid-card use and avoiding abrupt cessation after sustained or high-dose treatment.

Editorial contact: Doctor’s Passport editorial team. Source-check date is separate from clinical approval. Report a content problem · Content changes

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom