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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
RapidMLAMSRAGP

Oligoarthritis and polyarthritis

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Escalate

Arrange same-day assessment for sepsis with several hot joints, rapidly progressive weakness, severe systemic vasculitic features, threatened vision, myocarditis, major cytopenia or acute kidney injury. A single disproportionately hot joint within polyarthritis still requires aspiration for infection.

Synopsis

Convert a multi-joint complaint into a timed, anatomical and systemic phenotype, identify infection or organ-threatening disease, and refer persistent inflammatory arthritis before avoidable structural damage occurs.

  • Oligoarthritis involves a small number of joints and polyarthritis a broader multi-joint pattern, but count swollen joints rather than relying on the patient's word 'all over'.
  • Define onset, duration, symmetry, small- versus large-joint distribution, axial disease, enthesitis, dactylitis and whether inflammation is additive, migratory or episodic.
  • Examine skin, scalp, nails, eyes, mouth, lymph nodes and relevant cardiopulmonary, abdominal and neurological systems because extra-articular findings often decide the differential.

Key red flags

Infectious pattern

Fever, rash, exposure, immunosuppression, endocarditis risk or one destructive joint among several painful joints raises infection and requires urgent cultures and sampling.

Investigation priorities

01
Structured joint count and full-system examinationFirst step

Confirm synovitis, define distribution and find disease-defining extra-articular features.

Management branches

Systemically unwellFind infection or organ threat first

Polyarthritis with fever, shock, focal hot joint, renal change, visual symptoms, neuropathy or cardiopulmonary involvement.

  1. Stabilise physiology, obtain blood cultures and organ-directed tests, and aspirate any disproportionately inflamed accessible joint before antimicrobial treatment when safely possible.
  2. Contact the appropriate acute specialty and rheumatology; begin sepsis or organ-protection treatment according to the responsible pathway rather than awaiting a complete antibody panel.
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Sources and review status5 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom