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Educational draft · awaiting clinical reviewUse Rapid for revision, not patient-care decisions. Check current national and local guidance and the BNF or BNFC before acting.
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Bacterial vaginosis

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Discharge with pelvic danger

Pelvic pain, cervical motion tenderness, fever, pregnancy pain, significant bleeding or systemic illness is not uncomplicated bacterial vaginosis and may indicate PID, ectopic pregnancy or another acute disorder.

Action: Check pregnancy and observations, examine for upper-tract or surgical disease, obtain STI samples without delaying indicated antibiotics, and arrange urgent gynaecology or maternity care when red flags are present.

Synopsis

Diagnose bacterial vaginosis as a vaginal dysbiosis, choose an effective oral or intravaginal regimen, and manage pregnancy and recurrence without unnecessary partner antibiotics.

  • Bacterial vaginosis is vaginal dysbiosis with reduced lactobacilli and anaerobic biofilm; it commonly causes thin homogeneous grey-white discharge and fishy odour with little itch or inflammation.
  • Confirm with a Gram-stained vaginal smear using Hay–Ison or Nugent criteria, or with at least three of four Amsel criteria when point-of-care assessment is appropriate.
  • Vaginal pH above 4.5 supports BV but is not diagnostic because semen, blood and trichomoniasis can also increase pH.

Key red flags

Pelvic pain, fever, cervical motion or adnexal tenderness requires assessment for PID instead of repeated bacterial-vaginosis therapy.

Pregnancy with pain, bleeding, contractions, ruptured membranes or reduced fetal movement needs urgent maternity review.

Persistent blood-stained discharge, ulceration, contact bleeding or a mass requires cervical, vaginal or vulval assessment for neoplasia.

Severe vulval pain, spreading erythema, crepitus or systemic toxicity suggests invasive soft-tissue infection and requires emergency care.

Repeated malodour despite verified diagnosis and treatment should prompt examination for a retained foreign body and alternative infection.

Upper-tract warning

Pelvic pain, fever, cervical motion tenderness or adnexal tenderness indicates possible PID and requires broader urgent treatment.

Investigation priorities

01
Gram-stained vaginal smearFirst step

Grade lactobacillus depletion and BV-associated morphotypes using Hay–Ison or Nugent criteria.

Management branches

DIAGNOSEConfirm the dysbiosis pattern

A patient presents with thin malodorous discharge and little vulval inflammation.

  1. Ask about odour, itch, pain, bleeding, pregnancy, products, douching, antibiotics, retained material and sexual-health risks.
  2. Examine when indicated, measure vaginal pH and use Gram stain or Amsel criteria rather than relying on discharge colour alone.

Key medicines

Oral metronidazoleTake 400 mg orally twice daily for five to seven days for symptomatic bacterial vaginosis.Review warfarin, lithium, liver disease and neurological symptoms, and follow current product-specific advice about alcohol and breastfeeding.
Metronidazole vaginal gelApply 0.75% intravaginal gel once daily for five days using the supplied applicator.Confirm formulation and pregnancy suitability, explain local irritation, and do not substitute this regimen for systemic trichomoniasis treatment.
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Sources and review status3 sources · checked 13 Sept 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 13 Sept 2026; clinical approval remains outstanding.

Authoring stateRapid draftClinical stateAwaiting reviewJurisdictionUnited Kingdom