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Traumatic amputation and part preservation

Prioritise survival and haemorrhage control, protect the residual limb without blind clamping, package an amputated part correctly, minimise warm ischaemia through direct specialist transfer, and integrate replantation, revision amputation and lifelong rehabilitation decisions.

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Life-threatening bleeding precedes part salvage

Complete or near-complete amputation can exsanguinate rapidly, while crush, contamination, hypothermia and multisystem trauma determine survival and whether replantation can produce a useful limb.

Action: Use catastrophic-haemorrhage control and ABCDE, apply direct pressure, packing or the most distal effective tourniquet without blind clamping, activate major haemorrhage and trauma transfer, cover the stump and give open-injury antibiotics, wrap the part in saline-moistened gauze inside a sealed bag placed in iced water without direct ice contact, and contact the replantation centre immediately.

Open the sections you need. The overview is shown first.
01OverviewDefinition, clinical context and the essential points that orientate the chapter.

Use a catastrophic-haemorrhage-first trauma sequence. Apply firm direct pressure and haemostatic packing where anatomically possible. If bleeding remains life threatening, use a commercial tourniquet at the most distal position that controls flow and note the time visibly and in the record. Do not blindly clamp the wound because this can damage retracting nerves and vessels needed for repair. Activate major haemorrhage support, prevent hypothermia and search for head, chest, abdominal, pelvic and other limb injury.

Examine the residual limb after physiology permits. Record skin and muscle loss, contamination, fracture level, degloving and the apparent zones of crush or avulsion. Document proximal pulse, Doppler, compartments and every function still present in a near-amputation. A thin bridge must not be divided: it may contain a functioning nerve, vein or artery. Cover with saline-moistened sterile material, align gently and splint both the residual limb and any partially attached segment without tension or kinking.

Package a completely separated part immediately and correctly. Hold it with moistened sterile gauze rather than scrubbing. Remove only loose gross contamination. Wrap in gauze dampened with sterile saline, place inside a watertight sealed plastic bag and label it. Put that bag in an outer container of iced water. Tissue must not touch ice or dry ice, freeze, or sit directly in water. Record injury and cooling times and keep the package with the identified patient.

Call the appropriate replantation or major-trauma service at once. Communicate patient age and physiology, dominant side, occupation and goals, precise level, sharp versus crush or avulsion mechanism, contamination, associated injuries and estimated warm and cold ischaemia. Send policy-compliant images of the stump and part if requested without delaying transfer. Imaging of the residual skeleton and part can assist planning, but CT should not postpone haemorrhage control or direct transfer.

Replantation aims for useful function, not survival of tissue alone. Thumb, multiple digits, hand, wrist and paediatric injuries often prompt strong consideration; major proximal muscle-bearing segments have shorter tolerance and a greater reperfusion burden. Severe crush, long avulsion, multilevel destruction, heavy contamination, unstable physiology and limited reconstructive potential reduce benefit. No universal warm or cold time safely decides every tissue and level, so preserve and refer rather than rejecting a part locally.

Near-amputation or major limb replantation requires coordinated orthopaedic, plastic, vascular and anaesthetic surgery. Rapid temporary shunting may restore flow; skeletal shortening and stable fixation protect anastomoses, followed by arterial, venous, tendon, nerve and cover reconstruction in a planned sequence. Consider fasciotomy after revascularisation and monitor systemic potassium, CK, acid-base state and renal function. Debride non-viable contamination while retaining useful structures and avoid closure under tension.

When replantation is not appropriate, revision amputation still preserves maximal useful length, durable sensate cover, balanced muscle and prosthetic options. Do not sacrifice length or nerve unnecessarily during emergency tidying. A decision for early amputation of a mangled attached limb should involve at least two relevant consultants and the patient or family where possible, with rehabilitation expertise. Life-threatening sepsis, unsalvageable perfusion and predicted non-functional painful salvage shape the reasoning.

After either pathway, anticipate pain and adjustment needs. Provide multimodal analgesia, regional techniques under appropriate surveillance and early acute-pain input. Assess phantom sensation, neuroma, sleep, mood and post-traumatic stress without pathologising normal grief. Physiotherapy prevents contracture; occupational therapy supports independence and hand goals; rehabilitation medicine and prosthetics shape stump care, equipment and staged fitting. Peer support and vocational planning can materially improve long-term participation.

Key points

  • Control catastrophic haemorrhage first with direct pressure, packing or a commercial tourniquet placed as distally as effectively possible; record the exact application time and never use blind vascular clamps.
  • Do not shorten, complete or repeatedly debride the stump in the emergency department. Cover with a sterile saline-moistened dressing and protect bone, nerves and vessels for specialist revision or replantation.
  • Handle the part gently, remove only gross loose contamination, wrap it in sterile gauze moistened with saline and place it inside a sealed, labelled plastic bag.
  • Place the sealed bag in a second container containing iced water. Do not let tissue touch ice, freeze it, immerse it directly or place it loose in a refrigerator.
  • Label identity, side, anatomical level, injury time, cooling time and contamination and keep the part with the patient during direct trauma or replantation-centre transfer.
  • Contact the receiving specialist immediately with age, hand dominance, occupation, level, mechanism, contamination, warm and cold times, associated injuries and physiological status; do not await all imaging.
  • Replantation decisions consider life threat, level, muscle mass, ischaemia, crush or avulsion zone, contamination, comorbidity and likely useful function; a severity score cannot make the decision alone.
  • Begin antibiotics, tetanus care, pain and psychological support, then plan stump or replanted-limb monitoring, rehabilitation, prosthetics and return-to-life goals from admission.
02AetiologyUnderlying causes, associations and risk factors, with why each one matters.
01

Sharp guillotine injury

Clean division from machinery or a blade damages a relatively short tissue segment and generally offers better reconstructive anatomy than crush or avulsion.

02

Crush amputation

Heavy machinery, rail and road trauma destroy muscle, bone and microcirculation beyond the visible level and add rhabdomyolysis and contamination.

03

Avulsion injury

Traction strips vessels, nerves and skin over long distances, leaving occult proximal damage and a technically difficult replantation field.

04

Blast and ballistic trauma

High-energy fragmentation combines tissue loss, burns, contamination and multisystem injury, often requiring damage-control rather than immediate definitive reconstruction.

03PathophysiologyThe causal sequence from the underlying abnormality to symptoms and harm.
  1. 1
    Exsanguinating vessel injury

    Divided major arteries and veins produce external blood loss, while vasospasm or retraction can temporarily mask bleeding that recurs with resuscitation.

  2. 2
    Warm ischaemia

    Unperfused tissue consumes oxygen and accumulates metabolites; muscle-containing parts tolerate warm ischaemia poorly compared with digits and cool-preserved tissue.

  3. 3
    Cold metabolic slowing

    Correct indirect cooling reduces cellular metabolism and extends assessment time without the freeze injury caused by direct ice contact.

  4. 4
    Reperfusion burden

    Replanted or revascularised muscle releases potassium, acids and myoglobin and swells, creating arrhythmia, renal and compartment risks.

  5. 5
    Neuromuscular discontinuity

    Even successful vessel and bone repair requires meaningful nerve regeneration, tendon balance and joint function to produce a useful replanted limb.

04Clinical features and red flagsSymptoms, examination findings, patterns of presentation and time-critical warnings.
Complete sharp amputation

A clean short zone of division with a well-preserved part may offer favourable anatomy, but survival care and ischaemia time still dominate urgency.

Crush or avulsion zone

Irregular tissue, degloving and longitudinal vessel or nerve damage extend beyond the visible level and reduce predictable functional replantation.

Near-amputation

A distal part attached by limited skin or tendon with poor perfusion remains potentially reconstructable and must be splinted without completing separation.

Tourniquet-controlled stump

Bleeding may appear absent because a tourniquet is effective; time and location must remain visible and removal belongs in a controlled resuscitation or theatre plan.

Potential replantation candidate

Thumb, multiple digit, hand, wrist or paediatric amputation and selected clean major segments require immediate direct specialist discussion.

Physiologically dangerous limb

Massive crush, ischaemic muscle, contamination and shock can create systemic toxicity in which staged control or amputation may be life saving.

Red flags requiring action

  • Uncontrolled stump bleeding, shock, coagulopathy, hypothermia or associated torso and pelvic injury requires simultaneous resuscitation and operative haemorrhage control; replantation discussion must not delay survival care.
  • A partial amputation with a narrow tissue bridge, absent distal perfusion, venous congestion or progressive neurological loss is a dysvascular limb and must not be completed in the emergency department.
  • Direct ice or freezer contact, immersion in water, dry storage or failure to cool the sealed part accelerates tissue injury and can destroy otherwise viable replantation options.
  • Crush, avulsion, farm or water contamination and prolonged ischaemia reduce replantation feasibility and increase compartment, infection and systemic rhabdomyolysis risk, but specialist teams rather than a bedside score make the final decision.
05InvestigationsWhat to request, why it matters and how to interpret it.
Investigation order

Read from the initial assessment onwards. Tests may run in parallel in urgent care; first-line, preferred, confirmatory, definitive and gold-standard labels appear only when the chapter explicitly states them.

  1. 01
    First-line trauma physiologyFirst stepFirst line
    Why
    Identify haemorrhage, hypothermia, coagulopathy and associated life threat.
    Interpretation and limitations
    Use serial observations, blood gas and lactate, FBC, coagulation, fibrinogen, calcium, group and crossmatch and trauma imaging guided by response.
  2. 02
    Timed stump neurovascular examination
    Why
    Document remaining structures in a partial or near-amputation.
    Interpretation and limitations
    Record pulses, Doppler, capillary refill and named motor and sensory function before and after alignment, pressure control and splintage.
  3. 03
    Orthogonal skeletal radiographs
    Why
    Define bone level, comminution and fixation options in stump and separated part.
    Interpretation and limitations
    Image both when this does not delay transfer; include adjacent joints and retain clear identity labels.
  4. 04
    CT angiography
    Why
    Map vessels in a complex attached dysvascular limb when perfusion and time permit.
    Interpretation and limitations
    Use only if it changes the operative approach without delaying immediate revascularisation; a complete separated part usually proceeds by direct surgical assessment.
  5. 05
    Reperfusion metabolic panel
    Why
    Detect hyperkalaemia, rhabdomyolysis and kidney injury after prolonged ischaemia or replantation.
    Interpretation and limitations
    Trend ECG, potassium, blood gas, CK, creatinine, calcium, phosphate and urine output and treat potassium toxicity immediately.
  6. 06
    Microbiology and contamination assessment
    Why
    Guide treatment after farm, water or grossly contaminated injury.
    Interpretation and limitations
    Describe exposure and obtain deep operative specimens when infection is suspected; superficial part or stump swabs do not determine prophylaxis.
  7. 07
    Functional and rehabilitation assessment
    Why
    Estimate the likely utility of replantation, salvage or revision level.
    Interpretation and limitations
    Include dominance, occupation, baseline mobility, comorbidity, nerve level, prosthetic potential, patient goals and available rehabilitation resources.
06Differential diagnosisRealistic alternatives and the features that help distinguish them.
01

Near-amputation

A small remaining bridge can contain important vessels or nerves and must be protected and assessed as a dysvascular limb rather than divided.

02

Mangled but attached limb

Severe open fracture, degloving and arterial injury without complete separation requires the same salvage, shunt, fixation and orthoplastic pathway.

03

Isolated digit injury

Digit amputation has different functional indications, ischaemia tolerance and regional hand-centre referral than a muscle-rich major limb segment.

04

Devitalised soft-tissue fragment

A skin or muscle fragment without complete anatomical part may still offer graft or reconstruction value and should accompany the patient when safely packaged.

05

Pathological auto-amputation

Chronic vascular, diabetic or malignant tissue loss has different contamination and reconstruction biology from an acute traumatic event.

07ManagementImmediate care, first-line treatment, alternatives and escalation.
01ResuscitationControl bleeding and preserve optionsFirst stepA complete or near-complete traumatic amputation arrives with potential major haemorrhage.
  1. 1Run catastrophic haemorrhage and ABCDE care, using pressure, packing or the most distal effective tourniquet and recording its time.
  2. 2Activate blood-component resuscitation, TXA when indicated, warming and immediate trauma, orthopaedic and plastic or vascular support.
  3. 3Cover the stump without blind clamps or bedside shortening, give network open-injury prophylaxis and assess tetanus risk.
  4. 4Splint a near-amputation in alignment, repeat its perfusion and nerve examination and do not divide the remaining bridge.
02PartCool without freezingA body part is completely separated and available at the scene or hospital.
  1. 1Remove only loose gross dirt and wrap the part gently in sterile gauze moistened with saline.
  2. 2Seal it in a labelled watertight plastic bag and place that bag in an outer container of iced water.
  3. 3Prevent direct ice, dry ice, freezing, drying and direct water immersion and record injury and cooling times.
  4. 4Keep it with the identified patient and contact the replantation centre directly without waiting for all investigations.
03DefinitiveChoose useful reconstruction or revisionDefinitiveSpecialists know physiology, level, tissue zone, contamination, ischaemia and patient goals.
  1. 1Prioritise emergency flow, stable bone, vessel and nerve preservation and soft-tissue cover when replantation or salvage is credible.
  2. 2Monitor and treat reperfusion hyperkalaemia, rhabdomyolysis and compartment syndrome throughout and after reconstruction.
  3. 3When revision amputation is safer, preserve useful length and durable cover and plan nerves and muscle for prosthetic function.
  4. 4Begin pain, psychological, therapy, rehabilitation-medicine, prosthetic and vocational care during the acute admission.
Key medicines and prescribing safety2 treatments · regimens, roles and cautions
Reduces death from traumatic bleeding as an adjunct to tourniquet or operative control and balanced blood-component resuscitation.

Tranexamic acid for significant traumatic bleeding

For an adult within 3 hours of injury, give 1 g intravenously over 10 minutes followed by 1 g intravenously over 8 hours when active or suspected major bleeding meets the trauma protocol.

Do not delay surgical haemorrhage control, and do not initiate after 3 hours unless evidence of hyperfibrinolysis supports it; adjust maintenance exposure in significant renal impairment and review thrombosis risk.

Reduces infection risk in the contaminated stump and any part selected for replantation before formal operative debridement.

Immediate intravenous open-injury prophylaxis

Give the trauma network's specified intravenous agent at the current adult weight-based dose as soon as possible and ideally within 1 hour; record allergy, agent, dose and time and apply exposure-specific additions through microbiology.

Farm, aquatic, sewage, bite and resistant-organism exposure changes coverage; renal function, pregnancy and immediate allergy alter dose or agent, and antibiotics never replace tissue excision and timely cover.

08ComplicationsImportant consequences, why they occur and why they matter clinically.
01

Haemorrhagic shock

Ongoing or recurrent vessel bleeding causes coagulopathy, hypothermia, organ failure and death before definitive stump or replantation care.

02

Replantation failure

Thrombosis, venous congestion, infection or extensive zone injury can cause partial or complete tissue necrosis and secondary amputation.

03

Reperfusion and compartment injury

Returned flow to ischaemic muscle creates hyperkalaemia, rhabdomyolysis and swelling that may require renal support and fasciotomy.

04

Infection and wound breakdown

Contamination, dead tissue and poorly planned closure cause deep infection, osteomyelitis and repeated stump or flap surgery.

05

Chronic pain and disability

Neuroma, phantom pain, contracture, weakness and psychological trauma affect prosthetic use, work, identity and participation for years.

09Monitoring and follow-upTreatment response, safety checks and longer-term review.
  • Track haemodynamics, tourniquet time, blood loss, temperature, calcium, coagulation, lactate and transfusion response until definitive haemorrhage control.
  • Repeat stump or replanted-part colour, temperature, capillary refill, Doppler, congestion, swelling and named nerve findings at the specialist-prescribed frequency.
  • After reperfusion, monitor continuous ECG, potassium, blood gas, CK, creatinine, calcium, phosphate and urine output and treat deterioration immediately.
  • Inspect wounds, contamination, flap or graft, pin sites and tissue demarcation and return promptly for thrombosis, venous congestion, necrosis or infection.
  • Review antibiotic doses, renal function, operative cultures and tetanus completion and stop prophylaxis at the defined protocol point unless infection is diagnosed.
  • Follow residual-limb shape, skin, range, strength, sensation, neuroma and phantom pain, mood, independence, prosthetic use and work or participation goals.
10Special situationsVariants, exceptions and circumstances that change the usual approach.

Ice cools the bag, not the tissue

Indirect iced-water cooling slows metabolism, whereas direct ice contact freezes cells and can make replantation impossible.

A tissue bridge has value

Completing a near-amputation locally can divide the last draining vein, sensory nerve or useful skin and should be avoided.

Part survival is not functional success

A replanted segment needs recoverable nerves, tendons, joints and muscle to outperform a well-rehabilitated revision amputation.

Tourniquet time is a vital sign

Its location and application time must travel across every handover so haemorrhage control is not mistaken for spontaneous stability.

Preserve length thoughtfully

Every centimetre can affect prosthetic leverage and joint preservation, but non-viable tissue and unstable cover cannot be retained at any cost.

Rehabilitation starts before closure

Positioning, contracture prevention, pain education and patient goals shape later prosthetic and functional success from the first admission.

11Common pitfallsFrequent interpretation and management errors.
  1. 01

    Prioritising the separated part while uncontrolled stump bleeding or other major trauma threatens the patient's life.

  2. 02

    Blindly clamping the stump, completing a near-amputation or shortening bone before reconstructive review.

  3. 03

    Placing the part directly on ice, in a freezer, dry in a bag or immersed in water.

  4. 04

    Rejecting referral because a locally estimated ischaemia time or injury-severity score appears unfavourable.

  5. 05

    Removing a tourniquet in an uncontrolled environment or failing to document its position and time.

  6. 06

    Delaying pain, psychological, contracture and prosthetic rehabilitation until all wounds have healed.

Practice

Two practice questions

Question 1 of 20 correct
Musculoskeletal medicine and orthopaedicsOriginal SBA

Correct amputated-part packaging

A completely amputated hand arrives with the patient after machinery trauma. Which packaging method best preserves tissue during urgent specialist transfer?

Sources and review status6 sources · checked 27 Aug 2026 · clinical review pending
Sources

Sources and review status

National guidance is shown before implementation-dependent detail. Typical adult dose examples remain subject to patient factors, contraindications and the live BNF or specialist protocol. Source check completed 27 Aug 2026; clinical approval remains outstanding.

Authoring stateComplete draftClinical stateAwaiting reviewJurisdictionUnited Kingdom